YWHAB

YWHAB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BQ0, 2C23, 4DNK
Identifiers
Aliases	YWHAB, GW128, HEL-S-1, HS1, KCIP-1, YWHAA, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
External IDs	MGI: 1891917 HomoloGene: 20724 GeneCards: YWHAB
Gene ontology Molecular function • transcription corepressor activity • protein domain specific binding • protein complex binding • histone deacetylase binding • phosphoprotein binding • protein C-terminus binding • protein binding • enzyme binding • phosphoserine binding • cadherin binding Cellular component • cytoplasm • membrane • focal adhesion • melanosome • transcriptional repressor complex • protein complex • perinuclear region of cytoplasm • extracellular exosome • cytoplasmic vesicle membrane • nucleus • mitochondrion • cytosol Biological process • protein targeting • negative regulation of protein dephosphorylation • protein heterooligomerization • regulation of mRNA stability • positive regulation of catalytic activity • hippo signaling • cytoplasmic sequestering of protein • MAPK cascade • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • membrane organization • viral process • negative regulation of transcription, DNA-templated • negative regulation of G-protein coupled receptor protein signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7529	54401
Ensembl	ENSG00000166913	ENSMUSG00000018326
UniProt	P31946 Q4VY19	Q9CQV8
RefSeq (mRNA)	NM_139323 NM_003404	NM_018753
RefSeq (protein)	NP_003395 NP_647539	NP_061223.2 NP_061223
Location (UCSC)	Chr 20: 44.89 – 44.91 Mb	Chr 2: 163.99 – 164.02 Mb
PubMed search

2BQ0, 2C23, 4DNK

7529

54401

ENSG00000166913

ENSMUSG00000018326

P31946
Q4VY19

Q9CQV8

NM_139323
NM_003404

NM_018753

NP_003395
NP_647539

NP_061223.2
NP_061223

14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene.

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.

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Wikipedia