Jangsem Sherab Zangpo, also known as Jangsem Sherab Sangpo, (1395-1457) was a 15th-century Tibetan Buddhist monk and teacher, and one of the six contemporary disciples of Je Tsongkhapa, the founder of one of the newest school of Tibetan Buddhism, the Gelug school. He is crediting with establishing the famed Thikse Monastery and the remotely located Phugtal Monastery in Ladakh, in the North Indian state of Jammu and Kashmir.
Jangsem Sherab Zangpo is believed to have been born in 1395 in the village of Karma, in the Kham region of Tibet. Some claim that he was born in the village of Bershi, in the Nanchen county of Kham. He was the son of Bege Tongpon Rilu and Akyima.
At the age of seven, he received lay vows from Deshin Shekpa, 5th Karmapa Lama, the fifth Gyalwa Karmapa of the Kagyu school of Tibetan Buddhism. Design was on his way to or from China, gave Jangsen the name, Sherab Zangpo. After deciding to devote his life to religion, went off to study the traditions of the Karma Kagyu school under the Lamas of the Karma Gon Monastery. Choje Chopel Zangpo, a disciple of the first Pakpa Lha and Drukpa Gyelwang Choje, along with Rinchen Pelwai Khenpo, imparted Jangsem his basic education. The two teachers, along with Jamchopa Jamyang Drakpa, taught him sutras and tantra. He trained in particular in texts related to Avalokiteśvara, Vajravārahī, Dharmapala Bernagchen (a form of Mahākāla, Prajñāpāramitā and Bodhisattvacaryāvatāra.