Insulin receptor substrate 1

IRS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IRS, 1K3A, 1QQG, 2Z8C
Identifiers
Aliases	IRS1, HIRS-1, insulin receptor substrate 1
External IDs	OMIM: 147545 MGI: 99454 HomoloGene: 4049 GeneCards: IRS1
Gene location (Human) Chr. Chromosome 2 (human) Band 2q36.3 Start 226,731,317 bp End 226,799,759 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C5|1 42.0 cM Start 82,233,101 bp End 82,291,416 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • insulin-like growth factor receptor binding • transmembrane receptor protein tyrosine kinase adaptor activity • insulin receptor binding • SH2 domain binding • signal transducer activity • phosphatidylinositol 3-kinase binding • protein binding • protein kinase C binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphotyrosine residue binding Cellular component • cytoplasm • cytosol • intracellular membrane-bounded organelle • plasma membrane • caveola • nucleus • insulin receptor complex Biological process • positive regulation of fatty acid beta-oxidation • positive regulation of glucose import • insulin-like growth factor receptor signaling pathway • negative regulation of insulin secretion • positive regulation of glycogen biosynthetic process • glucose homeostasis • response to peptide hormone • positive regulation of glucose metabolic process • positive regulation of glucose import in response to insulin stimulus • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • response to insulin • negative regulation of insulin receptor signaling pathway • positive regulation of cell proliferation • cellular response to insulin stimulus • phosphatidylinositol 3-kinase signaling • positive regulation of insulin receptor signaling pathway • phosphatidylinositol-mediated signaling • signal transduction • insulin receptor signaling pathway • positive regulation of GTPase activity • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3667	16367
Ensembl	ENSG00000169047	ENSMUSG00000055980
UniProt	P35568	P35569
RefSeq (mRNA)	NM_005544	NM_010570
RefSeq (protein)	NP_005535	NP_034700
Location (UCSC)	Chr 2: 226.73 – 226.8 Mb	Chr 2: 82.23 – 82.29 Mb
PubMed search

1IRS, 1K3A, 1QQG, 2Z8C

3667

16367

ENSG00000169047

ENSMUSG00000055980

P35568

P35569

NM_005544

NM_010570

NP_005535

NP_034700

Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that in humans is encoded by the IRS-1 gene. It is a 131 kDa protein with amino acid sequence of 1242 residues. It contains a single pleckstrin homology (PH) domain at the N-terminus and a PTB domain ca. 40 residues downstream of this, followed by a poorly conserved C-terminus tail. Together with IRS2, IRS3 (pseudogene) and IRS4, it is homologous to the Drosophila protein chico, whose disruption extends the median lifespan of flies up to 48%. Similarly, Irs1 mutant mice experience moderate life extension and delayed age-related pathologies.

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