IRS4

IRS4
Identifiers
Aliases	IRS4, IRS-4, PY160, insulin receptor substrate 4
External IDs	HomoloGene: 136777 GeneCards: IRS4
Gene ontology Molecular function • phosphatidylinositol 3-kinase binding • protein binding • insulin receptor binding • SH3/SH2 adaptor activity • signal transducer activity Cellular component • cytosol • membrane • plasma membrane Biological process • insulin receptor signaling pathway • regulation of lipid metabolic process • signal transduction • positive regulation of signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8471	n/a
Ensembl	ENSG00000133124	n/a
UniProt	O14654	n/a
RefSeq (mRNA)	NM_003604	n/a
RefSeq (protein)	NP_003595	n/a
Location (UCSC)	Chr X: 108.73 – 108.74 Mb	n/a
PubMed search		n/a

8471

n/a

ENSG00000133124

n/a

O14654

n/a

NM_003604

n/a

NP_003595

n/a

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.

IRS4 has been shown to interact with CRK and NISCH.

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Wikipedia