NISCH

NISCH
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3P0C
Identifiers
Aliases	NISCH, I-1, IR1, IRAS, hIRAS, nischarin
External IDs	HomoloGene: 130564 GeneCards: NISCH
Gene ontology Molecular function • integrin binding • protein binding • phosphatidylinositol binding • identical protein binding Cellular component • cytoplasm • recycling endosome • cytosol • endosome • plasma membrane • early endosome • membrane Biological process • regulation of blood pressure • Rac protein signal transduction • negative regulation of cell migration • regulation of synaptic transmission, GABAergic • actin cytoskeleton organization • norepinephrine secretion • glucose metabolic process • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11188	n/a
Ensembl	ENSG00000010322	n/a
UniProt	Q9Y2I1	n/a
RefSeq (mRNA)	NM_001276293 NM_001276294 NM_007184	n/a
RefSeq (protein)	NP_001263222 NP_001263223 NP_009115	n/a
Location (UCSC)	Chr 3: 52.46 – 52.49 Mb	n/a
PubMed search		n/a

3P0C

11188

n/a

ENSG00000010322

n/a

Q9Y2I1

n/a

NM_001276293
NM_001276294
NM_007184

n/a

NP_001263222
NP_001263223
NP_009115

n/a

Nischarin is a protein that in humans is encoded by the NISCH gene.

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation.

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