CRK (gene)

CRK

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1JU5, 2DVJ, 2EYV, 2EYW, 2EYX, 2EYY, 2EYZ, 2MS4

Identifiers

Aliases

CRK, CRKII, p38, v-crk avian sarcoma virus CT10 oncogene homolog, CRK proto-oncogene, adaptor protein

External IDs

MGI: 88508 HomoloGene: 81850 GeneCards: CRK

Gene ontology
Molecular function	• protein binding, bridging • protein domain specific binding • ephrin receptor binding • SH2 domain binding • protein phosphorylated amino acid binding • protein binding • SH3/SH2 adaptor activity • enzyme binding • insulin-like growth factor receptor binding • cytoskeletal protein binding • scaffold protein binding • protein tyrosine kinase binding
Cellular component	• cytoplasm • cytosol • membrane • plasma membrane • actin cytoskeleton • extracellular exosome • nucleus • membrane raft
Biological process	• activation of MAPKK activity • Fc-gamma receptor signaling pathway involved in phagocytosis • regulation of GTPase activity • ephrin receptor signaling pathway • regulation of transcription from RNA polymerase II promoter • regulation of Rac protein signal transduction • vascular endothelial growth factor receptor signaling pathway • regulation of actin cytoskeleton organization • positive regulation of substrate adhesion-dependent cell spreading • response to yeast • positive regulation of smooth muscle cell migration • response to hepatocyte growth factor • response to hydrogen peroxide • negative regulation of natural killer cell mediated cytotoxicity • cellular response to transforming growth factor beta stimulus • cellular response to nitric oxide • response to peptide • cellular response to nerve growth factor stimulus • cellular response to insulin-like growth factor stimulus • cellular response to endothelin
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1398


12928

Ensembl


ENSG00000167193


ENSMUSG00000017776

UniProt


P46108


Q64010

RefSeq (mRNA)


NM_016823 NM_005206


NM_001277219 NM_001277221 NM_133656

RefSeq (protein)


NP_005197 NP_058431


NP_598417.2 NP_001264148 NP_001264150 NP_598417

Location (UCSC)

Chr 17: 1.42 – 1.46 Mb

Chr 11: 75.68 – 75.71 Mb

PubMed search

1JU5, 2DVJ, 2EYV, 2EYW, 2EYX, 2EYY, 2EYZ, 2MS4

NM_001277219
NM_001277221
NM_133656

NP_005197
NP_058431

NP_598417.2
NP_001264148
NP_001264150
NP_598417

...
Wikipedia