Hypocretin (orexin) receptor 2

HCRTR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4S0V
Identifiers
Aliases	HCRTR2, OX2R, Hypocretin (orexin) receptor 2, hypocretin receptor 2
External IDs	MGI: 2680765 HomoloGene: 1168 GeneCards: HCRTR2
Gene ontology Molecular function • peptide hormone binding • peptide binding • G-protein coupled receptor activity • signal transducer activity • neuropeptide receptor activity • orexin receptor activity Cellular component • integral component of membrane • plasma membrane • membrane • integral component of plasma membrane Biological process • phospholipase C-activating G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway • cellular response to hormone stimulus • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • signal transduction • response to peptide • chemical synaptic transmission • regulation of cytosolic calcium ion concentration • regulation of circadian sleep/wake cycle, wakefulness • neuropeptide signaling pathway • feeding behavior Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3062	387285
Ensembl	ENSG00000137252	ENSMUSG00000032360
UniProt	O43614	P58308
RefSeq (mRNA)	NM_001526	NM_198962
RefSeq (protein)	NP_001517	NP_945200
Location (UCSC)	Chr 6: 55.11 – 55.28 Mb	Chr 9: 76.23 – 76.32 Mb
PubMed search

Orexin receptor type 2
Identifiers
Symbol	Orexin_rec2
Pfam	PF03827
InterPro	IPR004060
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

4S0V

3062

387285

ENSG00000137252

ENSMUSG00000032360

O43614

P58308

NM_001526

NM_198962

NP_001517

NP_945200

Orexin receptor type 2 (Ox2R or OX₂), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene.

The structure of the receptor has been solved to 2.5 Å resolution as a fusion protein bound to suvorexant using lipid-mediated crystallization.

OX₂ is a G-protein coupled receptor expressed exclusively in the brain. It has 64% identity with OX₁. OX₂ binds both orexin A and orexin B neuropeptides. OX₂ is involved in the central feedback mechanism that regulates feeding behaviour.

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