Hypocretin (orexin) receptor 1

HCRTR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZJ8, 4ZJC
Identifiers
Aliases	HCRTR1, OX1R, Hypocretin (orexin) receptor 1, hypocretin receptor 1
External IDs	MGI: 2385650 HomoloGene: 37492 GeneCards: HCRTR1
Targeted by Drug
almorexant, filorexant, SB-334867, SB-649868, suvorexant
Gene ontology Molecular function • peptide hormone binding • peptide binding • G-protein coupled receptor activity • signal transducer activity • orexin receptor activity Cellular component • integral component of membrane • plasma membrane • membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • cellular response to hormone stimulus • regulation of circadian sleep/wake cycle, sleep • signal transduction • response to peptide • chemical synaptic transmission • regulation of cytosolic calcium ion concentration • positive regulation of ERK1 and ERK2 cascade • neuropeptide signaling pathway • feeding behavior Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3061	230777
Ensembl	ENSG00000121764	ENSMUSG00000028778
UniProt	O43613	P58307
RefSeq (mRNA)	NM_001525	NM_001163027 NM_198959 NM_001305392
RefSeq (protein)	NP_001516	NP_001156499.1 NP_945197.2 NP_001156499 NP_001292321 NP_945197
Location (UCSC)	Chr 1: 31.62 – 31.63 Mb	Chr 4: 130.13 – 130.14 Mb
PubMed search

4ZJ8, 4ZJC

3061

230777

ENSG00000121764

ENSMUSG00000028778

O43613

P58307

NM_001525

NM_001163027
NM_198959
NM_001305392

NP_001516

NP_001156499.1
NP_945197.2
NP_001156499
NP_001292321
NP_945197

Orexin receptor type 1 (Ox1R or OX₁), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene.

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