SB-334867

SB-334867

Identifiers
IUPAC name 1-(2-methylbenzoxazol-6-yl)-3-[1,5]naphthyridin-4-yl urea
CAS Number	249889-64-3 N
PubChem CID	6604926
IUPHAR/BPS	1703
ChemSpider	5037182 Y
ChEMBL	CHEMBL291536 Y
ECHA InfoCard	100.164.490
Chemical and physical data
Formula	C17H13N5O2
Molar mass	319.317 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(Nc1c2ncccc2ncc1)Nc3ccc4nc(oc4c3)C
InChI InChI=1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23) Y Key:AKMNUCBQGHFICM-UHFFFAOYSA-N Y
NY (what is this?)

SB-334867 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX₁, with around 50x selectivity for OX₁ over OX₂ receptors. It has been shown to produce sedative and anorectic effects in animals, and has been useful in characterising the orexinergic regulation of brain systems involved with appetite and sleep, as well as other physiological processes. Orexin antagonists have multiple potential clinical applications including the treatment of drug addiction, insomnia, obesity and diabetes.