HDAC2

HDAC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MAX, 4LXZ, 4LY1
Identifiers
Aliases	HDAC2, HD2, RPD3, YAF1, histone deacetylase 2
External IDs	MGI: 1097691 HomoloGene: 68187 GeneCards: HDAC2
Targeted by Drug
apicidin, Belinostat, butyric acid, entinostat, givinostat, mocetinostat, panobinostat, quisinostat, romidepsin, trichostatin A, vorinostat
Gene ontology Molecular function • nucleosomal DNA binding • heat shock protein binding • core promoter binding • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • enzyme binding • RNA polymerase II distal enhancer sequence-specific DNA binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • protein deacetylase activity • chromatin binding • NF-kappaB binding • protein binding • sequence-specific DNA binding • deacetylase activity • RNA polymerase II repressing transcription factor binding • hydrolase activity • histone deacetylase activity • RNA binding Cellular component • cytoplasm • nucleus • NuRD complex • ESC/E(Z) complex • Sin3 complex • nuclear chromatin • chromatin • nucleoplasm • protein complex • membrane • integral component of membrane Biological process • cellular response to retinoic acid • cellular response to heat • rhythmic process • response to amphetamine • negative regulation of DNA binding • cardiac muscle hypertrophy • positive regulation of tyrosine phosphorylation of Stat3 protein • odontogenesis of dentin-containing tooth • positive regulation of proteolysis • positive regulation of interleukin-1 production • response to cocaine • cellular response to transforming growth factor beta stimulus • positive regulation of collagen biosynthetic process • histone H3 deacetylation • chromatin remodeling • negative regulation of peptidyl-lysine acetylation • regulation of transcription, DNA-templated • response to nicotine • embryonic digit morphogenesis • negative regulation of MHC class II biosynthetic process • negative regulation of sequence-specific DNA binding transcription factor activity • transcription, DNA-templated • positive regulation of transcription, DNA-templated • histone H4 deacetylation • fungiform papilla formation • positive regulation of tumor necrosis factor production • response to caffeine • negative regulation of dendritic spine development • hair follicle placode formation • epidermal cell differentiation • positive regulation of oligodendrocyte differentiation • maintenance of chromatin silencing • negative regulation of neuron projection development • response to hyperoxia • dendrite development • positive regulation of receptor biosynthetic process • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • eyelid development in camera-type eye • positive regulation of epithelial to mesenchymal transition • circadian regulation of gene expression • ATP-dependent chromatin remodeling • response to lipopolysaccharide • behavioral response to ethanol • negative regulation of transcription, DNA-templated • cellular response to dopamine • blood coagulation • positive regulation of cell proliferation • histone deacetylation • response to drug • positive regulation of transcription from RNA polymerase II promoter • cellular response to hydrogen peroxide • regulation of signal transduction by p53 class mediator • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3066	15182
Ensembl	ENSG00000196591	ENSMUSG00000019777
UniProt	Q92769	P70288
RefSeq (mRNA)	NM_001527	NM_008229
RefSeq (protein)	NP_001518	NP_032255.2 NP_032255
Location (UCSC)	Chr 6: 113.93 – 114.01 Mb	Chr 10: 36.97 – 37 Mb
PubMed search

3MAX, 4LXZ, 4LY1

3066

15182

ENSG00000196591

ENSMUSG00000019777

Q92769

P70288

NM_001527

NM_008229

NP_001518

NP_032255.2
NP_032255

Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene.

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.

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