HCN2

HCN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MPF, 3U10
Identifiers
Aliases	HCN2, BCNG-2, BCNG2, HAC-1, hyperpolarization activated cyclic nucleotide gated potassium channel 2
External IDs	MGI: 1298210 HomoloGene: 31022 GeneCards: HCN2
Gene ontology Molecular function • nucleotide binding • potassium channel activity • cAMP binding • sodium channel activity • voltage-gated ion channel activity • ion channel activity • intracellular cAMP activated cation channel activity • identical protein binding • voltage-gated potassium channel activity • voltage-gated sodium channel activity Cellular component • integral component of membrane • membrane • voltage-gated potassium channel complex • plasma membrane • integral component of plasma membrane • HCN channel complex Biological process • cellular response to cGMP • sodium ion transmembrane transport • sodium ion transport • cell-cell signaling • regulation of membrane potential • regulation of ion transmembrane transport • ion transport • potassium ion transport • transmembrane transport • potassium ion transmembrane transport • transport • cellular response to cAMP • regulation of postsynaptic membrane potential • membrane depolarization during cardiac muscle cell action potential • sodium ion import across plasma membrane • potassium ion import across plasma membrane Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	610	15166
Ensembl	ENSG00000099822	ENSMUSG00000020331
UniProt	Q9UL51	O88703
RefSeq (mRNA)	NM_001194	NM_008226
RefSeq (protein)	NP_001185	NP_032252.1 NP_032252
Location (UCSC)	Chr 19: 0.59 – 0.62 Mb	Chr 10: 79.72 – 79.74 Mb
PubMed search

2MPF, 3U10

610

15166

ENSG00000099822

ENSMUSG00000020331

Q9UL51

O88703

NM_001194

NM_008226

NP_001185

NP_032252.1
NP_032252

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene.

HCN2 has been shown to interact with HCN1 and HCN4.

The function of the channel is not known although its activation by hyperpolarization alludes to the funny channels in the sinoatrial node of the heart (which form the basis of spontaneous generation of electrical rhythm). These channels have recently been associated with chronic pain and blocking the gene is associated with resolution of neuropathic episodes of pain.

...
Wikipedia