HCN1

HCN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3U0Z
Identifiers
Aliases	HCN1, BCNG-1, BCNG1, EIEE24, HAC-2, hyperpolarization activated cyclic nucleotide gated potassium channel 1
External IDs	MGI: 1096392 HomoloGene: 32093 GeneCards: HCN1
Gene location (Human) Chr. Chromosome 5 (human) Band 5p12 Start 45,254,950 bp End 45,696,498 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 D2.3|13 66.34 cM Start 117,602,320 bp End 117,987,418 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • intracellular cAMP activated cation channel activity • identical protein binding • voltage-gated sodium channel activity • ion channel activity • potassium channel activity • sodium channel activity • voltage-gated ion channel activity • voltage-gated potassium channel activity • voltage-gated cation channel activity • cAMP binding Cellular component • axon • membrane • dendrite • plasma membrane • integral component of membrane • HCN channel complex • integral component of plasma membrane Biological process • transmembrane transport • retinal cone cell development • regulation of ion transmembrane transport • apical protein localization • ion transport • sodium ion transport • regulation of membrane potential • sodium ion transmembrane transport • potassium ion transmembrane transport • regulation of postsynaptic membrane potential • potassium ion transport • protein homotetramerization • cellular response to cAMP • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	348980	15165
Ensembl	ENSG00000164588	ENSMUSG00000021730
UniProt	O60741	O88704
RefSeq (mRNA)	NM_021072	NM_010408
RefSeq (protein)	NP_066550	NP_034538
Location (UCSC)	Chr 5: 45.25 – 45.7 Mb	Chr 5: 117.6 – 117.99 Mb
PubMed search

3U0Z

348980

15165

ENSG00000164588

ENSMUSG00000021730

O60741

O88704

NM_021072

NM_010408

NP_066550

NP_034538

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.

HCN1 channel expression is found in the sinoatrial node, the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.

HCN1 has been shown to interact with HCN2.

De novo mutations in HCN1 cause epilepsy .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

...
Wikipedia