HCN4

HCN4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MNG, 3OTF, 3U11, 4HBN, 4KL1, 4NVP
Identifiers
Aliases	HCN4, SSS2, hyperpolarization activated cyclic nucleotide gated potassium channel 4
External IDs	MGI: 1298209 HomoloGene: 3997 GeneCards: HCN4
Gene location (Human) Chr. Chromosome 15 (human) Band No data available Start 73,319,859 bp End 73,369,264 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band No data available Start 58,823,412 bp End 58,863,175 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • potassium channel activity • cAMP binding • sodium channel activity • voltage-gated ion channel activity • ion channel activity • intracellular cAMP activated cation channel activity • identical protein binding • voltage-gated potassium channel activity • voltage-gated sodium channel activity • voltage-gated potassium channel activity involved in SA node cell action potential depolarization Cellular component • integral component of membrane • membrane • intrinsic component of plasma membrane • plasma membrane • perinuclear region of cytoplasm • HCN channel complex Biological process • cellular response to cGMP • muscle contraction • sodium ion transmembrane transport • sodium ion transport • SA node cell action potential • regulation of membrane potential • regulation of ion transmembrane transport • cation transport • ion transport • blood circulation • regulation of membrane depolarization • regulation of heart rate • potassium ion transport • transmembrane transport • potassium ion transmembrane transport • regulation of cardiac muscle contraction • regulation of heart rate by cardiac conduction • cellular response to cAMP • regulation of postsynaptic membrane potential • membrane depolarization during cardiac muscle cell action potential • membrane depolarization during SA node cell action potential • sodium ion import across plasma membrane • regulation of cardiac muscle cell action potential involved in regulation of contraction • potassium ion import across plasma membrane • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10021	330953
Ensembl	ENSG00000138622	ENSMUSG00000032338
UniProt	Q9Y3Q4	O70507
RefSeq (mRNA)	NM_005477	NM_001081192
RefSeq (protein)	NP_005468	NP_001074661
Location (UCSC)	Chr 15: 73.32 – 73.37 Mb	Chr 15: 58.82 – 58.86 Mb
PubMed search

2MNG, 3OTF, 3U11, 4HBN, 4KL1, 4NVP

10021

330953

ENSG00000138622

ENSMUSG00000032338

Q9Y3Q4

O70507

NM_005477

NM_001081192

NP_005468

NP_001074661

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene.

There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian heart. Some humans with bradycardia and Sick sinus syndrome have been shown to have mutations in their HCN4 gene. The role of HCN channels in autonomic control of heart rate is currently a matter of ongoing investigation.

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