GPR55

GPR55
Identifiers
Aliases	GPR55, LPIR1, G protein-coupled receptor 55
External IDs	MGI: 2685064 HomoloGene: 36184 GeneCards: GPR55
Gene ontology Molecular function • cannabinoid receptor activity • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • positive regulation of Rho protein signal transduction • G-protein coupled receptor signaling pathway • activation of phospholipase C activity • bone resorption • negative regulation of osteoclast differentiation • signal transduction • positive regulation of ERK1 and ERK2 cascade • cannabinoid signaling pathway • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9290	227326
Ensembl	ENSG00000135898	ENSMUSG00000049608
UniProt	Q9Y2T6	Q3UJF0
RefSeq (mRNA)	NM_005683	NM_001033290
RefSeq (protein)	NP_005674	NP_001028462
Location (UCSC)	Chr 2: 230.91 – 230.96 Mb	Chr 1: 85.94 – 85.96 Mb
PubMed search

9290

227326

ENSG00000135898

ENSMUSG00000049608

Q9Y2T6

Q3UJF0

NM_005683

NM_001033290

NP_005674

NP_001028462

G protein-coupled receptor 55 also known as GPR55 is a G protein-coupled receptor that in humans is encoded by the GPR55 gene.

GPR55, along with GPR119 and GPR18, have been implicated as novel cannabinoid receptors.

GPR55 was identified and cloned for the first time in 1999. Later it was identified by an in silico screen as a putative cannabinoid receptor because of a similar amino acid sequence in the binding region. Research groups from Glaxo Smith Kline and Astra Zeneca characterized the receptor extensively because it was hoped to be responsible for the blood pressure lowering properties of cannabinoids. GPR55 is indeed activated by endogenous, plant and synthetic cannabinoids but GPR-55 knockout mice generated by a research group from Glaxo Smith Kline showed no altered blood pressure regulation after administration of the cannabidiol-derivative abnormal cannabidiol.

...
Wikipedia