GPR18

GPR18
Identifiers
Aliases	GPR18, G protein-coupled receptor 18
External IDs	MGI: 107859 HomoloGene: 18814 GeneCards: GPR18
Gene ontology Molecular function • signal transducer activity • G-protein coupled receptor activity Cellular component • integral component of membrane • plasma membrane • membrane • integral component of plasma membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle Biological process • signal transduction • G-protein coupled receptor signaling pathway • CD8-positive, alpha-beta intraepithelial T cell differentiation • negative regulation of tumor necrosis factor production • CD8-positive, gamma-delta intraepithelial T cell differentiation • negative regulation of leukocyte chemotaxis • T cell differentiation • positive regulation of Rho protein signal transduction • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2841	110168
Ensembl	ENSG00000125245	ENSMUSG00000050350
UniProt	Q14330	Q8K1Z6
RefSeq (mRNA)	NM_001098200 NM_005292	NM_182806
RefSeq (protein)	NP_001091670 NP_005283	NP_877958.1 NP_877958
Location (UCSC)	Chr 13: 99.25 – 99.26 Mb	Chr 14: 121.91 – 121.92 Mb
PubMed search

2841

110168

ENSG00000125245

ENSMUSG00000050350

Q14330

Q8K1Z6

NM_001098200
NM_005292

NM_182806

NP_001091670
NP_005283

NP_877958.1
NP_877958

N-arachidonyl glycine receptor also known as G-protein coupled receptor 18 (GPR18) is a protein that in humans is encoded by the GPR18 gene. Along with the other previously "orphan" receptors GPR55 and GPR119, GPR18 has been found to be a receptor for endogenous lipid neurotransmitters, several of which also bind to cannabinoid receptors.

Research supports the hypothesis that GPR18 is the abnormal cannabidiol receptor and N-arachidonoyl glycine, the endogenous lipid metabolite of anandamide, initiates directed microglial migration in the CNS through activation of GPR18, though recent evidence demonstrates that NAGly was not shown to be a GPR18 agonist in rat sympathetic neurons.

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Wikipedia