GPR119

GPR119
Identifiers
Aliases	GPR119, GPCR2, G protein-coupled receptor 119
External IDs	MGI: 2668412 HomoloGene: 18670 GeneCards: GPR119
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • phosphatidylcholine binding • lipid binding Cellular component • integral component of membrane • receptor complex • plasma membrane • membrane Biological process • G-protein coupled receptor signaling pathway • insulin secretion • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	139760	236781
Ensembl	ENSG00000147262	ENSMUSG00000051209
UniProt	Q8TDV5	Q7TQP3
RefSeq (mRNA)	NM_178471	NM_181751
RefSeq (protein)	NP_848566	NP_861416
Location (UCSC)	Chr X: 130.38 – 130.39 Mb	Chr X: 48.67 – 48.67 Mb
PubMed search

139760

236781

ENSG00000147262

ENSMUSG00000051209

Q8TDV5

Q7TQP3

NM_178471

NM_181751

NP_848566

NP_861416

G protein-coupled receptor 119 also known as GPR119 is a G protein-coupled receptor that in humans is encoded by the GPR119 gene.

GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors.

GPR119 is expressed predominantly in the pancreas and gastrointestinal tract in rodents and humans, as well as in the brain in rodents. Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats. GPR119 has also been shown to regulate incretin and insulin hormone secretion. As a result, new drugs acting on the receptor have been suggested as novel treatments for obesity and diabetes.

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Wikipedia