GNRHR

GNRHR
Identifiers
Aliases	GNRHR, GNRHR1, GRHR, HH7, LHRHR, LRHR, gonadotropin releasing hormone receptor
External IDs	OMIM: 138850 MGI: 95790 HomoloGene: 350 GeneCards: GNRHR
Targeted by Drug
buserelin, goserelin, histrelin, leuprolide, triptorelin, abarelix, cetrorelix, elagolix, sufugolix, relugolix
Gene ontology Molecular function • protein-hormone receptor activity • signal transducer activity • G-protein coupled receptor activity • peptide binding • gonadotropin-releasing hormone receptor activity Cellular component • plasma membrane • membrane • integral component of membrane • integral component of plasma membrane Biological process • multicellular organism development • signal transduction • G-protein coupled receptor signaling pathway • cellular response to gonadotropin-releasing hormone Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2798	14715
Ensembl	ENSG00000109163	ENSMUSG00000029255
UniProt	P30968	Q01776
RefSeq (mRNA)	NM_001012763 NM_000406	NM_010323 NM_001310651 NM_001310653
RefSeq (protein)	NP_000397 NP_001012781	NP_034453.1 NP_001297580 NP_001297582 NP_034453
Location (UCSC)	Chr 4: 67.74 – 67.75 Mb	Chr 5: 86.18 – 86.2 Mb
PubMed search

2798

14715

ENSG00000109163

ENSMUSG00000029255

P30968

Q01776

NM_001012763
NM_000406

NM_010323
NM_001310651
NM_001310653

NP_000397
NP_001012781

NP_034453.1
NP_001297580
NP_001297582
NP_034453

Gonadotropin-releasing hormone receptor is a protein that in humans is encoded by the GNRHR gene.

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

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Wikipedia