GABRA1

GABRA1
Identifiers
Aliases	GABRA1, ECA4, EIEE19, EJM, EJM5, gamma-aminobutyric acid type A receptor alpha1 subunit
External IDs	MGI: 95613 HomoloGene: 629 GeneCards: GABRA1
Targeted by Drug
gaboxadol, isonipecotic acid, isoguvacine, muscimol, ZK93423, flumazenil, L-838417, ZK93426, bretazenil, indiplon, ocinaplon, L-822179, methyl 6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate, ro-15-4513, RO4938581, alprazolam, clonazepam, diazepam, flunitrazepam, zolpidem, triazolam, bicuculline, picrotoxin, CGS8216
Gene ontology Molecular function • ion channel activity • GABA receptor activity • drug binding • chloride channel activity • extracellular ligand-gated ion channel activity • GABA-gated chloride ion channel activity • GABA-A receptor activity • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • integral component of plasma membrane • synapse • chloride channel complex • cell junction • GABA receptor complex • cytoplasmic vesicle membrane • cytoplasmic vesicle • GABA-A receptor complex Biological process • gamma-aminobutyric acid signaling pathway • synaptic transmission, GABAergic • ion transport • ion transmembrane transport • transport • chloride transport • cellular response to histamine • chloride transmembrane transport • regulation of postsynaptic membrane potential • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2554	14394
Ensembl	ENSG00000022355	ENSMUSG00000010803
UniProt	P14867	P62812
RefSeq (mRNA)	NM_001127648 NM_000806 NM_001127643 NM_001127644 NM_001127645 NM_001127646 NM_001127647	NM_010250
RefSeq (protein)	NP_000797 NP_001121115 NP_001121116 NP_001121117 NP_001121120	NP_034380.1 NP_034380
Location (UCSC)	Chr 5: 161.85 – 161.9 Mb	Chr 11: 42.13 – 42.18 Mb
PubMed search

2554

14394

ENSG00000022355

ENSMUSG00000010803

P14867

P62812

NM_001127646
NM_001127647

NM_010250

NP_000797
NP_001121115
NP_001121116
NP_001121117
NP_001121120

NP_034380.1
NP_034380

Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene.

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.

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Wikipedia