France–Americas relations started in the 16th century, soon after the discovery of the New World by Christopher Columbus, and have developed over a period of several centuries.
In order to counterbalance the power of the Habsburg Empire under Charles Quint, and especially its control of large parts of the New World through the Crown of Spain, Francis I endeavoured to develop contacts with the New World and Asia.
In 1524, Francis I assisted the citizens of Lyon in financing the expedition of Giovanni da Verrazzano to North America. Verrazzano was an Italian in the service of the French crown. The objective was to explore the lands north of Florida and find a passage to Cathay. Verrazzano was the first European since the Norse colonization of the Americas around AD 1000 to explore the Atlantic coast of North America between South and North Carolina and Newfoundland, including New York Harbor and Narragansett Bay in 1524: in between, John Cabot had already explored Labrador to the North, and the Spanish had already settled parts of Florida. On this expedition, Verrazzano claimed Newfoundland for the French crown.
In 1531, Bertrand d'Ornesan, Baron de Saint-Blancard tried to establish a French trading post at Pernambuco, Brazil.
In 1534, Francis sent Jacques Cartier to explore the St. Lawrence River in Quebec to find "certain islands and lands where it is said he should find great quantities of gold and other rich things". In 1541, Francis sent Jean-François de la Roque de Roberval to settle Canada and to provide for the spread of "the Holy Catholic faith."