Fibromodulin

FMOD
Identifiers
Aliases	FMOD, FM, SLRR2E, fibromodulin
External IDs	MGI: 1328364 HomoloGene: 1530 GeneCards: FMOD
Gene ontology Molecular function • heparin binding • Roundabout binding Cellular component • Golgi lumen • extracellular region • extracellular matrix • lysosomal lumen • proteinaceous extracellular matrix • extracellular space Biological process • transforming growth factor beta receptor complex assembly • keratan sulfate biosynthetic process • keratan sulfate catabolic process • axonogenesis • collagen fibril organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2331	14264
Ensembl	ENSG00000122176	ENSMUSG00000041559
UniProt	Q06828	P50608
RefSeq (mRNA)	NM_002023	NM_021355
RefSeq (protein)	NP_002014	NP_067330.1 NP_067330
Location (UCSC)	Chr 1: 203.34 – 203.35 Mb	Chr 1: 134.04 – 134.05 Mb
PubMed search

2331

14264

ENSG00000122176

ENSMUSG00000041559

Q06828

P50608

NM_002023

NM_021355

NP_002014

NP_067330.1
NP_067330

Fibromodulin is a protein that in humans is encoded by the FMOD gene.

Fibromodulin is a 42kDa protein of a family of small interstitial leucine-rich repeat proteoglycans (SLRPs). It can have up to four N-linked keratan sulfate chains attached to the core protein within the leucine-rich region. It shares significant sequence homology with biglycan and decorin.

Fibromodulin participates in the assembly of the collagen fibers of the extracellular matrix. It binds to the same site on the collagen type I molecule as lumican. It also inhibits fibrillogenesis of collagen type I and collagen type III in vitro. It regulates TGF-beta activities by sequestering TGF-beta into the extracellular matrix.

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Wikipedia