Decorin

DCN
Identifiers
Aliases	DCN, Dcn, DC, DSPG2, PG40, PGII, PGS2, SLRR1B, mDcn, CSCD, decorin
External IDs	MGI: 94872 HomoloGene: 22430 GeneCards: DCN
Gene ontology Molecular function • collagen binding • protein N-terminus binding • protein kinase inhibitor activity • glycosaminoglycan binding • extracellular matrix binding • protein binding • RNA binding Cellular component • cytoplasm • extracellular matrix • proteinaceous extracellular matrix • extracellular region • lysosomal lumen • Golgi lumen • collagen type VI trimer • extracellular space Biological process • glycosaminoglycan metabolic process • positive regulation of mitochondrial fission • negative regulation of protein kinase activity • positive regulation of autophagy • kidney development • cytokine-mediated signaling pathway • placenta development • chondroitin sulfate biosynthetic process • response to mechanical stimulus • aging • extracellular matrix disassembly • extracellular matrix organization • wound healing • negative regulation of endothelial cell migration • positive regulation of macroautophagy • response to lipopolysaccharide • positive regulation of mitochondrial depolarization • animal organ morphogenesis • chondroitin sulfate catabolic process • negative regulation of angiogenesis • positive regulation of phosphatidylinositol 3-kinase signaling • peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan • negative regulation of vascular endothelial growth factor signaling pathway • dermatan sulfate biosynthetic process • skeletal muscle tissue development • positive regulation of transcription from RNA polymerase II promoter • negative regulation of JAK-STAT cascade Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1634	13179
Ensembl	ENSG00000011465	ENSMUSG00000019929
UniProt	P07585	P28654
RefSeq (mRNA)	NM_001920 NM_133503 NM_133504 NM_133505 NM_133506 NM_133507	NM_001190451 NM_007833
RefSeq (protein)	NP_001911 NP_598010 NP_598011 NP_598012 NP_598013 NP_598014	NP_001177380.1 NP_031859.1 NP_001177380 NP_031859
Location (UCSC)	Chr 12: 91.14 – 91.18 Mb	Chr 10: 97.48 – 97.52 Mb
PubMed search

1634

13179

ENSG00000011465

ENSMUSG00000019929

P07585

P28654

NM_133507

NM_001190451
NM_007833

NP_598014

NP_001177380.1
NP_031859.1
NP_001177380
NP_031859

Decorin is a protein that in humans is encoded by the DCN gene.

Decorin is a proteoglycan that is on average 90 - 140 kilodaltons (kDa) in molecular weight. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS).

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Wikipedia