FREM2

FREM2
Identifiers
Aliases	FREM2, FRAS1 related extracellular matrix protein 2
External IDs	MGI: 2444465 HomoloGene: 18454 GeneCards: FREM2
Gene location (Human) Chr. Chromosome 13 (human) Band n/a Start 38,687,129 bp End 38,887,131 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band n/a Start 53,513,938 bp End 53,657,355 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding Cellular component • plasma • membrane • basement membrane • integral component of membrane • extracellular exosome Biological process • multicellular organism development • morphogenesis of an epithelium • inner ear development • heart development • cell communication • cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	341640	242022
Ensembl	ENSG00000150893	ENSMUSG00000037016
UniProt	Q5SZK8	Q6NVD0
RefSeq (mRNA)	NM_207361	NM_172862
RefSeq (protein)	NP_997244	NP_766450
Location (UCSC)	Chr 13: 38.69 – 38.89 Mb	Chr 13: 53.51 – 53.66 Mb
PubMed search

341640

242022

ENSG00000150893

ENSMUSG00000037016

Q5SZK8

Q6NVD0

NM_207361

NM_172862

NP_997244

NP_766450

FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.

This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.

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Wikipedia