FGF4

FGF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IJT
Identifiers
Aliases	FGF4, HBGF-4, HST, HST-1, HSTF1, K-FGF, KFGF, fibroblast growth factor 4
External IDs	MGI: 95518 HomoloGene: 1522 GeneCards: FGF4
Gene ontology Molecular function • heparin binding • fibroblast growth factor receptor binding • growth factor activity • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity Cellular component • extracellular region • intracellular Biological process • cartilage condensation • MAPK cascade • phosphatidylinositol-mediated signaling • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • apoptotic process involved in morphogenesis • signal transduction • cell-cell signaling • regulation of endothelial cell chemotaxis to fibroblast growth factor • multicellular organism development • embryonic limb morphogenesis • mesenchymal cell proliferation • positive regulation of cell division • regulation of gene expression • positive regulation of gene expression • stem cell population maintenance • chondroblast differentiation • cranial suture morphogenesis • positive regulation of transcription from RNA polymerase II promoter • cell differentiation • positive regulation of protein phosphorylation • odontogenesis of dentin-containing tooth • embryonic hindlimb morphogenesis • fibroblast growth factor receptor signaling pathway • peptidyl-tyrosine phosphorylation • positive regulation of cell proliferation • positive regulation of GTPase activity • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2249	14175
Ensembl	ENSG00000075388	ENSMUSG00000050917
UniProt	P08620	P11403
RefSeq (mRNA)	NM_002007	NM_010202
RefSeq (protein)	NP_001998	NP_034332.2 NP_034332
Location (UCSC)	Chr 11: 69.77 – 69.78 Mb	Chr 7: 144.85 – 144.87 Mb
PubMed search

1IJT

2249

14175

ENSG00000075388

ENSMUSG00000050917

P08620

P11403

NM_002007

NM_010202

NP_001998

NP_034332.2
NP_034332

Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

...
Wikipedia