FGF3

FGF3
Identifiers
Aliases	FGF3, HBGF-3, INT2, fibroblast growth factor 3
External IDs	MGI: 95517 HomoloGene: 3841 GeneCards: FGF3
Gene ontology Molecular function • fibroblast growth factor receptor binding • protein binding • growth factor activity • Ras guanyl-nucleotide exchange factor activity • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • protein tyrosine kinase activity Cellular component • extracellular region • intracellular Biological process • cell differentiation • cell-cell signaling • anatomical structure morphogenesis • MAPK cascade • multicellular organism development • fibroblast growth factor receptor signaling pathway • negative regulation of cardiac muscle tissue development • positive regulation of cell proliferation • positive regulation of cell division • phosphatidylinositol-mediated signaling • signal transduction • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process • peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2248	14174
Ensembl	ENSG00000186895	ENSMUSG00000031074
UniProt	P11487	n/a
RefSeq (mRNA)	NM_005247	NM_008007
RefSeq (protein)	NP_005238	n/a
Location (UCSC)	Chr 11: 69.81 – 69.82 Mb	Chr 7: 144.84 – 144.84 Mb
PubMed search

2248

14174

ENSG00000186895

ENSMUSG00000031074

P11487

n/a

NM_005247

NM_008007

NP_005238

n/a

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.

FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. Also, haploinsufficiency in the FGF3 gene is thought to cause otodental syndrome.

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