Fibroblast growth factor receptor 3

FGFR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RY7, 2LZL, 4K33
Identifiers
Aliases	FGFR3, ACH, CD333, CEK2, HSFGFR3EX, JTK4, fibroblast growth factor receptor 3
External IDs	MGI: 95524 HomoloGene: 55437 GeneCards: FGFR3
Targeted by Drug
nintedanib
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein binding • transmembrane receptor protein tyrosine kinase activity • fibroblast growth factor binding • fibroblast growth factor-activated receptor activity • ATP binding • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity Cellular component • cytoplasm • integral component of membrane • Golgi apparatus • membrane • focal adhesion • plasma membrane • integral component of plasma membrane • transport vesicle • extracellular region • cell surface • endoplasmic reticulum • cytoplasmic vesicle • nucleus Biological process • bone mineralization • JAK-STAT cascade • chondrocyte differentiation • phosphorylation • negative regulation of developmental growth • cell-cell signaling • bone morphogenesis • endochondral ossification • positive regulation of tyrosine phosphorylation of Stat3 protein • bone maturation • fibroblast growth factor receptor apoptotic signaling pathway • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of phospholipase activity • fibroblast growth factor receptor signaling pathway • protein phosphorylation • chondrocyte proliferation • positive regulation of cell proliferation • positive regulation of ERK1 and ERK2 cascade • protein autophosphorylation • peptidyl-tyrosine phosphorylation • endochondral bone growth • phosphatidylinositol-mediated signaling • positive regulation of tyrosine phosphorylation of Stat1 protein • positive regulation of MAPK cascade • apoptotic process • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process • skeletal system development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2261	14184
Ensembl	ENSG00000068078	ENSMUSG00000054252
UniProt	P22607	Q61851
RefSeq (mRNA)	NM_000142 NM_001163213 NM_022965	NM_001163215 NM_001163216 NM_001163217 NM_001205270 NM_008010
RefSeq (protein)	NP_000133 NP_001156685 NP_075254	n/a
Location (UCSC)	Chr 4: 1.79 – 1.81 Mb	Chr 5: 33.72 – 33.74 Mb
PubMed search

1RY7, 2LZL, 4K33

2261

14184

ENSG00000068078

ENSMUSG00000054252

P22607

Q61851

NM_000142
NM_001163213
NM_022965

NM_001163215
NM_001163216
NM_001163217
NM_001205270
NM_008010

NP_000133
NP_001156685
NP_075254

n/a

Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster of differentiation 333). The gene is located on chromosome 4q16.3 is "expressed in tissues such as the cartilage, brain, intestine, and kidneys."

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Wikipedia