FBLN1

FBLN1
Identifiers
Aliases	FBLN1, FBLN, FIBL1, fibulin 1
External IDs	MGI: 95487 HomoloGene: 21295 GeneCards: FBLN1
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.31 Start 45,502,238 bp End 45,601,135 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E2 Start 85,205,949 bp End 85,286,535 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • fibronectin binding • calcium ion binding • extracellular matrix structural constituent • fibrinogen binding • integrin binding • protein C-terminus binding • protein binding • identical protein binding • peptidase activator activity Cellular component • elastic fiber • extracellular matrix • proteinaceous extracellular matrix • fibrinogen complex • basement membrane • extracellular exosome • extracellular space • extracellular region Biological process • negative regulation of protein phosphorylation • negative regulation of cell adhesion • negative regulation of stem cell proliferation • positive regulation of fibroblast proliferation • positive regulation of substrate-dependent cell migration, cell attachment to substrate • negative regulation of transforming growth factor-beta secretion • negative regulation of cell motility • negative regulation of transformation of host cell by virus • positive regulation of peptidase activity • positive regulation of gene expression • negative regulation of ERK1 and ERK2 cascade • integrin-mediated signaling pathway • blood coagulation, fibrin clot formation • negative regulation of substrate adhesion-dependent cell spreading • viral process • embryo implantation • extracellular matrix organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2192	14114
Ensembl	ENSG00000077942	ENSMUSG00000006369
UniProt	P23142	Q08879
RefSeq (mRNA)	NM_006487 NM_001996 NM_006485 NM_006486	NM_010180 NM_001347088
RefSeq (protein)	NP_001987 NP_006476 NP_006477 NP_006478	NP_001334017 NP_034310
Location (UCSC)	Chr 22: 45.5 – 45.6 Mb	Chr 22: 85.21 – 85.29 Mb
PubMed search

2192

14114

ENSG00000077942

ENSMUSG00000006369

P23142

Q08879

NM_006487
NM_001996
NM_006485
NM_006486

NM_010180
NM_001347088

NP_001987
NP_006476
NP_006477
NP_006478

NP_001334017
NP_034310

FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein.

Fibulin-1 is a secreted glycoprotein that is found in association with extracellular matrix structures including fibronectin-containing fibers, elastin-containing fibers and basement membranes. Fibulin-1 binds to a number of extracellular matrix constituents including fibronectin,nidogen-1, and the proteoglycan, versican. Fibulin-1 is also a blood protein capable of binding to fibrinogen.

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Wikipedia