Epidermal growth factor receptor

EGFR

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes

1IVO, 1M14, 1M17, 1MOX, 1NQL, 1XKK, 1YY9, 1Z9I, 2EB2, 2EB3, 2GS2, 2GS6, 2GS7, 2ITN, 2ITO, 2ITP, 2ITQ, 2ITT, 2ITU, 2ITV, 2ITW, 2ITY, 2ITZ, 2J5E, 2J5F, 2J6M, 2JIT, 2JIU, 2JIV, 2KS1, 2M0B, 2M20, 2RF9, 2RFD, 2RFE, 2RGP, 3B2U, 3B2V, 3BEL, 3BUO, 3C09, 3G5V, 3G5Y, 3GOP, 3GT8, 3IKA, 3LZB, 3NJP, 3OB2, 3OP0, 3P0Y, 3PFV, 3POZ, 3QWQ, 3UG1, 3UG2, 3VJN, 3VJO, 3VRP, 3VRR, 3W2O, 3W2P, 3W2Q, 3W2R, 3W2S, 3W32, 3W33, 4G5J, 4G5P, 4HJO, 4I1Z, 4I20, 4I21, 4I22, 4I23, 4I24, 4JQ7, 4JQ8, 4JR3, 4JRV, 4KRL, 4KRM, 4KRO, 4KRP, 4LI5, 4LL0, 4LQM, 4LRM, 4R3P, 4R3R, 4R5S, 4RIW, 4RIX, 4RIY, 4RJ4, 4RJ5, 4RJ6, 4RJ7, 4RJ8, 4TKS, 4WKQ, 4WRG, 4ZJV, 5CNN, 5CNO, 5CAN, 2N5S, 5CAL, 5C8M, 4UV7, 5CAV, 5CZI, 5EDQ, 5CAS, 5CAO, 5CAP, 5EM5, 5HG5, 5EDR, 5EM8, 5EDP, 5HG7, 5CAU, 5C8K, 5C8N, 5CZH, 5CAQ, 5EM6, 4UIP, 5HG9, 5EM7, 5HG8, 4ZSE, 5HIB, 5HIC, 5D41, 4WD5

Identifiers

Aliases

EGFR, ERBB, ERBB1, HER1, NISBD2, PIG61, mENA, epidermal growth factor receptor

External IDs

MGI: 95294 HomoloGene: 74545 GeneCards: EGFR

Genetically Related Diseases

malignant glioma

Targeted by Drug

afatinib, 5-chloro-N2-(4-(4-(dimethylamino)-1-piperidinyl)-2-methoxyphenyl)-N4-(2-(dimethylphosphinyl)phenyl)-2,4-pyrimidinediamine, canertinib, dacomitinib anhydrous, erlotinib, gefitinib, icotinib, lapatinib, neratinib, vandetanib, osimertinib

Gene ontology
Molecular function	• kinase activity • nitric-oxide synthase regulator activity • transmembrane receptor protein tyrosine kinase activity • protein phosphatase binding • ATP binding • protein kinase activity • signal transducer, downstream of receptor, with protein tyrosine kinase activity • enzyme binding • MAP kinase kinase kinase activity • transferase activity • chromatin binding • actin filament binding • protein binding • double-stranded DNA binding • transmembrane signaling receptor activity • nucleotide binding • signal transducer activity • identical protein binding • receptor binding • protein tyrosine kinase activity • calmodulin binding • protein kinase binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • protein heterodimerization activity • glycoprotein binding • Ras guanyl-nucleotide exchange factor activity • integrin binding • epidermal growth factor binding • epidermal growth factor-activated receptor activity • ubiquitin protein ligase binding • cadherin binding
Cellular component	• cytoplasm • endosome • multivesicular body, internal vesicle lumen • nuclear membrane • membrane • focal adhesion • extracellular region • perinuclear region of cytoplasm • nucleus • cell surface • endoplasmic reticulum • integral component of membrane • Golgi apparatus • early endosome membrane • receptor complex • plasma membrane • endocytic vesicle • intracellular • AP-2 adaptor complex • endosome membrane • endoplasmic reticulum membrane • Golgi membrane • basolateral plasma membrane • Shc-EGFR complex • membrane raft • apical plasma membrane • synapse • extracellular space • clathrin-coated vesicle membrane
Biological process	• positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle • positive regulation of protein phosphorylation • negative regulation of epidermal growth factor receptor signaling pathway • positive regulation of MAP kinase activity • protein phosphorylation • cell surface receptor signaling pathway • protein insertion into membrane • cell proliferation • morphogenesis of an epithelial fold • positive regulation of protein kinase B signaling • epidermal growth factor receptor signaling pathway • ossification • negative regulation of protein catabolic process • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of fibroblast proliferation • activation of phospholipase C activity • epidermis development • learning or memory • protein autophosphorylation • positive regulation of phosphorylation • cerebral cortex cell migration • digestive tract morphogenesis • hair follicle development • single organismal cell-cell adhesion • phosphorylation • positive regulation of epithelial cell proliferation • embryonic placenta development • eyelid development in camera-type eye • activation of phospholipase A2 activity by calcium-mediated signaling • positive regulation of DNA replication • response to UV-A • phosphatidylinositol-mediated signaling • regulation of peptidyl-tyrosine phosphorylation • positive regulation of cell migration • positive regulation of catenin import into nucleus • positive regulation of nitric oxide biosynthetic process • cellular response to estradiol stimulus • positive regulation of DNA repair • response to stress • regulation of nitric-oxide synthase activity • salivary gland morphogenesis • MAPK cascade • cellular response to epidermal growth factor stimulus • multicellular organism development • regulation of cell proliferation • cell morphogenesis • cellular response to amino acid stimulus • signal transduction • positive regulation of transcription from RNA polymerase II promoter • positive regulation of GTPase activity • lung development • positive regulation of synaptic transmission, glutamatergic • positive regulation of ERK1 and ERK2 cascade • phosphatidylinositol phosphorylation • circadian rhythm • positive regulation of superoxide anion generation • positive regulation of cell proliferation • positive regulation of vasoconstriction • response to osmotic stress • tongue development • negative regulation of apoptotic process • response to cobalamin • liver regeneration • response to calcium ion • wound healing • cellular response to dexamethasone stimulus • cellular response to drug • negative regulation of mitotic cell cycle • cellular response to growth factor stimulus • hydrogen peroxide metabolic process • response to oxidative stress • response to lipid • regulation of cell motility • activation of MAPKK activity • intracellular signal transduction • response to organic cyclic compound • magnesium ion homeostasis • translation • positive regulation of production of miRNAs involved in gene silencing by miRNA • positive regulation of smooth muscle cell proliferation • positive regulation of bone resorption • midgut development • positive regulation of inflammatory response • liver development • diterpenoid metabolic process • ERBB2 signaling pathway • response to estradiol • positive regulation of cell growth • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of prolactin secretion • astrocyte activation • cellular response to mechanical stimulus • response to hydroxyisoflavone • neuron projection morphogenesis • ovulation cycle • regulation of transcription from RNA polymerase II promoter • peptidyl-tyrosine phosphorylation • peptidyl-tyrosine autophosphorylation • membrane organization • positive regulation of protein kinase C activity • negative regulation of ERBB signaling pathway • positive regulation of protein localization to plasma membrane • negative regulation of cardiocyte differentiation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1956


13649

Ensembl


ENSG00000146648


ENSMUSG00000020122

UniProt


P00533


Q01279

RefSeq (mRNA)


NM_201284 NM_005228 NM_201282 NM_201283


NM_007912 NM_207655

RefSeq (protein)

NP_001333826 NP_001333827 NP_001333828 NP_001333829 NP_001333870
NP_005219 NP_958439 NP_958440 NP_958441


NP_997538.1 NP_031938 NP_997538

Location (UCSC)

Chr 7: 55.02 – 55.26 Mb

Chr 11: 16.75 – 16.92 Mb

PubMed search

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