EGLN2

EGLN2
Identifiers
Aliases	EGLN2, EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1, egl-9 family hypoxia inducible factor 2
External IDs	MGI: 1932287 HomoloGene: 14204 GeneCards: EGLN2
Gene ontology Molecular function • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors • L-ascorbic acid binding • iron ion binding • dioxygenase activity • metal ion binding • protein binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • ferrous iron binding • oxygen sensor activity • peptidyl-proline 4-dioxygenase activity Cellular component • nucleoplasm • nucleus Biological process • response to hypoxia • positive regulation of protein catabolic process • regulation of neuron apoptotic process • peptidyl-proline hydroxylation to 4-hydroxy-L-proline • cell redox homeostasis • regulation of cell growth • regulation of transcription from RNA polymerase II promoter in response to hypoxia • oxidation-reduction process • intracellular estrogen receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	112398	112406
Ensembl	ENSG00000269858	ENSMUSG00000058709
UniProt	Q96KS0	Q91YE2
RefSeq (mRNA)	NM_080732 NM_017555 NM_053046	NM_053208
RefSeq (protein)	NP_444274 NP_542770	NP_444438
Location (UCSC)	Chr 19: 40.8 – 40.81 Mb	Chr 7: 27.16 – 27.17 Mb
PubMed search

112398

112406

ENSG00000269858

ENSMUSG00000058709

Q96KS0

Q91YE2

NM_080732
NM_017555
NM_053046

NM_053208

NP_444274
NP_542770

NP_444438

Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene.

The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degradation by prolyl hydroxylation. This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.

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Wikipedia