Dopamine beta hydroxylase

DBH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZEL
Identifiers
Aliases	DBH, DBM, Dopamine beta-monooxygenase, dopamine beta-hydroxylase, Dopamine β-hydroxylase
External IDs	MGI: 94864 HomoloGene: 615 GeneCards: DBH
EC number	1.14.17.1
Targeted by Drug
nepicastat
Gene ontology Molecular function • metal ion binding • monooxygenase activity • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen • L-ascorbic acid binding • catalytic activity • dopamine beta-monooxygenase activity • copper ion binding Cellular component • cytoplasm • transport vesicle membrane • integral component of membrane • chromaffin granule lumen • chromaffin granule membrane • cytoplasmic vesicle • membrane • extracellular region • extracellular space • secretory granule membrane • secretory granule lumen • intracellular membrane-bounded organelle Biological process • response to amphetamine • chemical synaptic transmission • homoiothermy • leukocyte mediated immunity • visual learning • fear response • behavioral response to ethanol • locomotory behavior • regulation of extrinsic apoptotic signaling pathway • regulation of cell proliferation • positive regulation of vasoconstriction • glucose homeostasis • maternal behavior • memory • leukocyte migration • response to pain • oxidation-reduction process • blood vessel remodeling • cytokine production • associative learning • catecholamine biosynthetic process • dopamine catabolic process • norepinephrine biosynthetic process • octopamine biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1621	13166
Ensembl	ENSG00000123454	ENSMUSG00000000889
UniProt	P09172	Q64237
RefSeq (mRNA)	NM_000787	NM_138942
RefSeq (protein)	NP_000778	NP_620392.2 NP_620392
Location (UCSC)	Chr 9: 133.64 – 133.66 Mb	Chr 2: 27.17 – 27.18 Mb
PubMed search

dopamine beta-monooxygenase
Identifiers
EC number	1.14.17.1
CAS number	9013-38-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

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PMC	articles
PubMed	articles
NCBI	proteins

4ZEL

1621

13166

ENSG00000123454

ENSMUSG00000000889

P09172

Q64237

NM_000787

NM_138942

NP_000778

NP_620392.2
NP_620392

Dopamine beta-hydroxylase (DBH), also known as dopamine beta-monooxygenase, is an enzyme (EC 1.14.17.1) that in humans is encoded by the DBH gene. Dopamine beta-hydroxylase catalyzes the chemical reaction:

The three substrates of this enzyme are 3,4-dihydroxyphenethylamine, ascorbate, and O₂, whereas its three products are noradrenaline, dehydroascorbate, and H₂O.

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