Daniel Spencer (July 20, 1794 – December 8, 1868) was the last mayor of Nauvoo, Illinois prior to the revocation of its first charter.
Spencer was born in . In 1840, he joined the Church of Jesus Christ of Latter Day Saints. He soon after baptized his brother Orson Spencer.
Spencer served as a missionary to Canada in 1841.
Spencer left Nauvoo in February 1846. In Winter Quarters, Nebraska he served as a bishop. He arrived in the Salt Lake Valley in 1847 with the Perregrine Sessions Mormon pioneer company.
From 1852 to 1856 Spencer served as a missionary in the British Isles.
From 1849 to 1868 he served as president of the Salt Lake City Stake of the LDS Church.