DNA-PKcs

PRKDC
Identifiers
Aliases	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350, IMD26, protein kinase, DNA-activated, catalytic polypeptide
External IDs	MGI: 104779 HomoloGene: 5037 GeneCards: PRKDC
Gene ontology Molecular function • transferase activity • nucleotide binding • DNA binding • DNA-dependent protein kinase activity • transcription factor binding • kinase activity • protein serine/threonine kinase activity • protein binding • enzyme binding • ATP binding • RNA binding • double-stranded DNA binding • protein kinase activity • protein domain specific binding Cellular component • cytosol • membrane • transcription factor complex • nucleoplasm • DNA-dependent protein kinase-DNA ligase 4 complex • nonhomologous end joining complex • nuclear chromosome, telomeric region • extracellular matrix • nucleus • protein-DNA complex • protein complex • nucleolus Biological process • somitogenesis • negative regulation of protein phosphorylation • response to ionizing radiation • negative regulation of response to gamma radiation • positive regulation of immune system process • DNA recombination • positive regulation of developmental growth • T cell differentiation in thymus • signal transduction involved in mitotic G1 DNA damage checkpoint • telomere capping • phosphorylation • rhythmic process • thymus development • positive regulation of fibroblast proliferation • lymphocyte differentiation • T cell receptor V(D)J recombination • negative regulation of apoptotic process • double-strand break repair via alternative nonhomologous end joining • spleen development • negative regulation of immunoglobulin production • response to activity • regulation of smooth muscle cell proliferation • cellular response to DNA damage stimulus • heart development • pro-B cell differentiation • brain development • B cell lineage commitment • cellular protein modification process • peptidyl-serine phosphorylation • protein destabilization • regulation of circadian rhythm • intrinsic apoptotic signaling pathway in response to DNA damage • V(D)J recombination • cellular response to insulin stimulus • positive regulation of apoptotic process • ectopic germ cell programmed cell death • immunoglobulin V(D)J recombination • cell proliferation • double-strand break repair via nonhomologous end joining • telomere maintenance • response to gamma radiation • positive regulation of type I interferon production • T cell lineage commitment • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cellular senescence • immunoglobulin production • double-strand break repair • DNA repair • protein ubiquitination • protein phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5591	19090
Ensembl	ENSG00000253729	ENSMUSG00000022672
UniProt	P78527	P97313
RefSeq (mRNA)	NM_001081640 NM_006904	NM_011159
RefSeq (protein)	NP_001075109 NP_008835	NP_035289
Location (UCSC)	Chr 8: 47.77 – 47.96 Mb	Chr 16: 15.64 – 15.84 Mb
PubMed search

5591

19090

ENSG00000253729

ENSMUSG00000022672

P78527

P97313

NM_001081640
NM_006904

NM_011159

NP_001075109
NP_008835

NP_035289

DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that in humans is encoded by the gene designated as PRKDC or XRCC7. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. The DNA-Pkcs protein is a serine/threonine protein kinase comprising a single polypeptide chain of 4,128 amino acids.

DNA-PKcs is the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase called DNA-PK. The second component is the autoimmune antigen Ku. On its own, DNA-PKcs is inactive and relies on Ku to direct it to DNA ends and trigger its kinase activity. DNA-PKcs is required for the non-homologous end joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote immune system diversity. DNA-PKcs knockout mice have severe combined immunodeficiency due to their V(D)J recombination defect.

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Wikipedia