Cyclooxygenase-2

PTGS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR
Identifiers
Aliases	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin-endoperoxide synthase 2
External IDs	MGI: 97798 HomoloGene: 31000 GeneCards: PTGS2
Targeted by Drug
aspirin, benzquinamide, carprofen, celecoxib, diclofenac, etodolac, etoricoxib, flurbiprofen, ibuprofen, ketoprofen, ketorolac, lumiracoxib, meclofenamic acid, mefenamic acid, meloxicam, naproxen, nimesulide, NS-398, oxaprozin, acetaminophen, phenylbutazone, piroxicam, resveratrol, rofecoxib, suprofen, valdecoxib
Gene ontology Molecular function • arachidonate 15-lipoxygenase activity • metal ion binding • heme binding • enzyme binding • oxidoreductase activity • protein homodimerization activity • dioxygenase activity • protein binding • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • lipid binding • peroxidase activity • prostaglandin-endoperoxide synthase activity Cellular component • cytoplasm • endoplasmic reticulum lumen • membrane • caveola • neuron projection • nucleus • organelle membrane • endoplasmic reticulum • intracellular membrane-bounded organelle • protein complex • endoplasmic reticulum membrane Biological process • movement of cell or subcellular component • response to fructose • negative regulation of cell cycle • learning • response to organic substance • lipoxygenase pathway • cellular response to mechanical stimulus • response to manganese ion • angiogenesis • cellular response to hypoxia • embryo implantation • negative regulation of cell proliferation • prostaglandin metabolic process • response to cytokine • negative regulation of smooth muscle contraction • memory • response to oxidative stress • maintenance of permeability of blood-brain barrier • response to lithium ion • response to tumor necrosis factor • fatty acid biosynthetic process • positive regulation of synaptic transmission, glutamatergic • positive regulation of vasoconstriction • response to organonitrogen compound • inflammatory response • positive regulation of smooth muscle contraction • bone mineralization • response to fatty acid • response to vitamin D • cellular response to UV • positive regulation of fever generation • cellular response to fluid shear stress • positive regulation of synaptic plasticity • regulation of blood pressure • response to lipopolysaccharide • positive regulation of platelet-derived growth factor production • regulation of inflammatory response • brown fat cell differentiation • sensory perception of pain • response to radiation • prostaglandin biosynthetic process • cellular response to ATP • ovulation • positive regulation of smooth muscle cell proliferation • hair cycle • response to estradiol • positive regulation of cell death • positive regulation of cell migration involved in sprouting angiogenesis • response to organic cyclic compound • lipid metabolic process • positive regulation of nitric oxide biosynthetic process • response to glucocorticoid • cyclooxygenase pathway • fatty acid metabolic process • positive regulation of fibroblast growth factor production • decidualization • regulation of cell proliferation • positive regulation of cell proliferation • negative regulation of calcium ion transport • positive regulation of apoptotic process • positive regulation of transforming growth factor beta production • positive regulation of vascular endothelial growth factor production • positive regulation of NF-kappaB import into nucleus • oxidation-reduction process • positive regulation of brown fat cell differentiation • negative regulation of synaptic transmission, dopaminergic • response to drug • cellular oxidant detoxification • aging • NAD biosynthesis via nicotinamide riboside salvage pathway • cellular response to heat • positive regulation of prostaglandin biosynthetic process • positive regulation of peptidyl-serine phosphorylation • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cellular response to non-ionic osmotic stress • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5743	19225
Ensembl	ENSG00000073756	ENSMUSG00000032487
UniProt	P35354	Q05769
RefSeq (mRNA)	NM_000963	NM_011198
RefSeq (protein)	NP_000954	NP_035328.2 NP_035328
Location (UCSC)	Chr 1: 186.67 – 186.68 Mb	Chr 1: 150.1 – 150.11 Mb
PubMed search

5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR

5743

19225

ENSG00000073756

ENSMUSG00000032487

P35354

Q05769

NM_000963

NM_011198

NP_000954

NP_035328.2
NP_035328

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (The HUGO official symbol is PTGS2; HGNC ID, HGNC:9605), also known as cyclooxygenase-2 or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. In humans it is one of two cyclooxygenases. It is involved in the conversion of arachidonic acid to prostaglandin H2, an important precursor of prostacyclin, among others.

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