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Cyclooxygenase-2

PTGS2
6COX.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin-endoperoxide synthase 2
External IDs MGI: 97798 HomoloGene: 31000 GeneCards: PTGS2
Targeted by Drug
aspirin, benzquinamide, carprofen, celecoxib, diclofenac, etodolac, etoricoxib, flurbiprofen, ibuprofen, ketoprofen, ketorolac, lumiracoxib, meclofenamic acid, mefenamic acid, meloxicam, naproxen, nimesulide, NS-398, oxaprozin, acetaminophen, phenylbutazone, piroxicam, resveratrol, rofecoxib, suprofen, valdecoxib
RNA expression pattern
PBB GE PTGS2 204748 at.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000963

NM_011198

RefSeq (protein)

NP_000954

NP_035328.2
NP_035328

Location (UCSC) Chr 1: 186.67 – 186.68 Mb Chr 1: 150.1 – 150.11 Mb
PubMed search

5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR

NM_000963

NM_011198

NP_000954

NP_035328.2
NP_035328

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (The HUGO official symbol is PTGS2; HGNC ID, HGNC:9605), also known as cyclooxygenase-2 or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. In humans it is one of two cyclooxygenases. It is involved in the conversion of arachidonic acid to prostaglandin H2, an important precursor of prostacyclin, among others.


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Wikipedia

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