Names | |
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Preferred IUPAC name
2-Amino-1-methyl-5H-imidazol-4-one
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Systematic IUPAC name
2-Amino-1-methyl-1H-imidazol-4-ol
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Other names
2-Amino-1-methylimidazol-4-ol
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Identifiers | |
3D model (Jmol)
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3DMet | B00175 |
112061 | |
ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.000.424 |
EC Number | 200-466-7 |
KEGG | |
MeSH | Creatinine |
PubChem CID
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UNII | |
UN number | 1789 |
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Properties | |
C4H7N3O | |
Molar mass | 113.12 g·mol−1 |
Appearance | White crystals |
Density | 1.09 g cm−3 |
Melting point | 300 °C (572 °F; 573 K) (decomposes) |
1 part per 12 90 mg/ml at 20° C |
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log P | -1.76 |
Acidity (pKa) | 12.309 |
Basicity (pKb) | 1.688 |
Isoelectric point | 11.19 |
Thermochemistry | |
138.1 J K−1 mol−1 (at 23.4 °C) | |
Std molar
entropy (S |
167.4 J K−1 mol−1 |
Std enthalpy of
formation (ΔfH |
−240.81–239.05 kJ mol−1 |
Std enthalpy of
combustion (ΔcH |
−2.33539–2.33367 MJ mol−1 |
Hazards | |
EU classification (DSD)
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Xn |
R-phrases | R34, R36/37/38, R20/21/22 |
S-phrases | S26, S36/37/39, S45, S24/25, S36 |
NFPA 704 | |
Flash point | 290 °C (554 °F; 563 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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what is ?) | (|
Infobox references | |
90 mg/ml at 20° C
Creatinine (/kriˈætᵻnᵻn/ or /kriˈætᵻniːn/; from Greek: κρέας, translit. kreas, lit. 'flesh') is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass).
Serum creatinine (a blood measurement) is an important indicator of renal health because it is an easily measured byproduct of muscle metabolism that is excreted unchanged by the kidneys. Creatinine itself is produced via a biological system involving creatine, phosphocreatine (also known as creatine phosphate), and adenosine triphosphate (ATP, the body's immediate energy supply).
Creatine is synthesized primarily in the liver from the methylation of glycocyamine (guanidino acetate, synthesized in the kidney from the amino acids arginine and glycine) by S-adenosyl methionine. It is then transported through blood to the other organs, muscle, and brain, where, through phosphorylation, it becomes the high-energy compound phosphocreatine. Creatine conversion to phosphocreatine is catalyzed by creatine kinase; spontaneous formation of creatinine occurs during the reaction.