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Glycocyamine

Glycocyamine
Skeletal formula of a glycocyamine minor tautomer
Ball and stick model of a glycocyamine minor tautomer
Spacefill model of a glycocyamine minor tautomer
Names
Other names
2-Guanidinoacetic acid
Identifiers
3D model (JSmol)
3DMet B00139
1759179
ChEBI
ChemSpider
DrugBank
ECHA InfoCard 100.005.936
EC Number 206-529-5
KEGG
MeSH glycocyamine
PubChem CID
UNII
Properties
C3H7N3O2
Molar mass 117.11 g·mol−1
Appearance White crystals
Odor Odourless
Melting point 300 °C (572 °F; 573 K)
log P −1.11
Acidity (pKa) 3.414
Basicity (pKb) 10.583
Hazards
GHS pictograms The exclamation-mark pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
GHS signal word WARNING
H315, H319, H335
P261, P305+351+338
Related compounds
Related alkanoic acids
Related compounds
Dimethylacetamide
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YesYN ?)
Infobox references

Glycocyamine (or guanidinoacetate) is a metabolite of glycine in which the amino group has been converted into a guanidine.

Glycocyamine is a direct precursor of creatine and is used as a supplement. However the metabolism of creatine from glycocyamine in the liver causes a depletion of methyl groups. This causes homocysteine levels to rise, which has been shown to produce cardiovascular and skeletal problems.

A series of studies showed that a combination of betaine and glycocyamine improves the symptoms of patients with chronic illness, including heart disease, without toxicity. Betaine can provide a methyl group to glycocyamine, via methionine, for the formation of creatine. In overall, such treatment led to less fatigue, greater strength and endurance, and an improved sense of well-being. The patients with cardiac decompensation (arteriosclerosis or rheumatic disease) and congestive heart failure had improved cardiac function. The patients gained weight (improved nitrogen balance) and saw lessened symptoms of arthritis and asthma and increased libido, and those people suffering from hypertension experienced transient reduced blood pressure. Also the studies shows the increase of glucose tolerance in both diabetic subjects and subjects without diabetes.


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