Gene ontology
Molecular function	• transferase activity • transferase activity, transferring acyl groups • choline O-acetyltransferase activity
Cellular component	• cytoplasm • cytosol • nucleus • presynapse
Biological process	• neurotransmitter biosynthetic process • phosphatidylcholine biosynthetic process • neurotransmitter secretion
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1103


12647

Ensembl


ENSG00000070748


ENSMUSG00000021919

UniProt


P28329


n/a

RefSeq (mRNA)

NM_020986 NM_001142929 NM_001142933 NM_001142934 NM_020549
NM_020984 NM_020985


NM_009891

RefSeq (protein)

NP_001136401 NP_001136405 NP_001136406 NP_065574 NP_066264
NP_066265 NP_066266


n/a

Location (UCSC)

Chr 10: 49.61 – 49.67 Mb

Chr 14: 32.41 – 32.47 Mb

PubMed search

2FY2, 2FY3, 2FY4, 2FY5

n/a

n/a

Choline acetyltransferase (commonly abbreviated as ChAT, but sometimes CAT) is a transferase enzyme responsible for the synthesis of the neurotransmitter acetylcholine. ChAT catalyzes the transfer of an acetyl group from the coenzyme, acetyl-CoA, to choline yielding acetylcholine (ACh). ChAT is found in high concentration in cholinergic neurons, both in the central nervous system (CNS) and peripheral nervous system (PNS). As with most of nerve terminal proteins, ChAT is produced in the body of the neuron and is transported to the nerve terminal, where its concentration is highest. Presence of ChAT in a nerve cell classifies this cell as a "cholinergic" neuron. In humans, the choline acetyltransferase enzyme is encoded by the CHAT gene.

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Wikipedia