Charles Brenner
| Charles Brenner | |
|---|---|
| Born | October 30, 1961 |
| Residence | Iowa City, IA |
| Nationality | USA |
| Fields | Enzymology Metabolism |
| Institutions |
University of Iowa Dartmouth Medical School Thomas Jefferson University |
| Alma mater |
Wesleyan University (B.A.) Stanford University (Ph.D) Brandeis University (Post-Doctoral) |
| Thesis | Specificity and Activity of the Kex2 Protease: From Yeast Genetics to Enzyme Kinetics (1993) |
| Doctoral advisor | Robert S. Fuller |
| Other academic advisors |
Gregory A. Petsko Dagmar Ringe |
| Doctoral students | Shawn K. Milano Peter Belenky Katrina L. Bogan Jennifer A. Boyston Bo-Kuan Wu Samuel A.J. Trammell |
| Other notable students | Pawel Bieganowski Rebecca L. Fagan |
| Known for | New steps in nicotinamide adenine dinucleotide metabolism |
| Influences | Kunihiro Matsumoto Arthur Kornberg |
| Notable awards |
William E.M. Lands Lectureship Fellow of the American Association for the Advancement of Science Beckman Young Investigators Award ASBMB Award for Exemplary Contributions to Education |
|
Website biochem |
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Charles Brenner born October 30, 1961 is the Roy J. Carver Chair of Biochemistry and a director of the Obesity Initiative at the University of Iowa. He is a major contributor to work on nicotinamide adenine dinucleotide metabolism, who discovered the eukaryotic nicotinamide riboside kinase pathway.
Brenner is a graduate of Wesleyan University and a veteran of biotechnology companies, having worked at Chiron Corporation and DNAX Research Institute, prior to graduate school at Stanford University School of Medicine. Brenner conducted post-doctoral research at Brandeis University with Gregory Petsko and then took his first academic position at Thomas Jefferson University in 1996, moving to Dartmouth Medical School in 2003, where he served as Associate Director for Basic Sciences at Norris Cotton Cancer Center. He was recruited to chair biochemistry at Iowa in 2009.
Brenner has made multiple contributions to molecular biology and biochemistry, beginning with purification and characterization of the Kex2 proprotein convertase at Stanford. He has been funded by agencies including the Leukemia & Lymphoma Society, the March of Dimes, the Burroughs Wellcome Fund, the Beckman Foundation, the Lung Cancer Research Foundation, the National Institutes of Health, and the National Science Foundation. Significant research projects include molecular dissection of the function of the FHIT tumor suppressor gene, characterization and inhibition of DNA methylation, and discovery of new steps in nicotinamide adenine dinucleotide metabolism.
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