CYP4F2

CYP4F2
Identifiers
Aliases	CYP4F2, CPF2, cytochrome P450 family 4 subfamily F member 2
External IDs	MGI: 1919304 HomoloGene: 128623 GeneCards: CYP4F2
Gene ontology Molecular function • iron ion binding • arachidonic acid omega-hydroxylase activity • alpha-tocopherol omega-hydroxylase activity • arachidonic acid epoxygenase activity • tocotrienol omega-hydroxylase activity • tocopherol omega-hydroxylase activity • metal ion binding • alkane 1-monooxygenase activity • protein binding • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen • leukotriene-B4 20-monooxygenase activity • 20-aldehyde-leukotriene B4 20-monooxygenase activity • 20-hydroxy-leukotriene B4 omega oxidase activity • monooxygenase activity Cellular component • cytoplasm • organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • membrane • apical plasma membrane • endoplasmic reticulum • integral component of membrane Biological process • leukotriene metabolic process • epoxygenase P450 pathway • very long-chain fatty acid metabolic process • icosanoid metabolic process • blood coagulation • negative regulation of icosanoid secretion • pressure natriuresis • regulation of blood pressure • vitamin E metabolic process • phylloquinone catabolic process • omega-hydroxylase P450 pathway • renal water homeostasis • drug metabolic process • positive regulation of icosanoid secretion • sodium ion homeostasis • long-chain fatty acid metabolic process • vitamin K catabolic process • menaquinone catabolic process • oxidation-reduction process • leukotriene B4 catabolic process • arachidonic acid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8529	72054
Ensembl	ENSG00000186115	ENSMUSG00000003484
UniProt	P78329	Q99N16
RefSeq (mRNA)	NM_001082	NM_024444
RefSeq (protein)	NP_001073	NP_077764
Location (UCSC)	Chr 19: 15.88 – 15.9 Mb	Chr 8: 71.99 – 72.01 Mb
PubMed search

8529

72054

ENSG00000186115

ENSMUSG00000003484

P78329

Q99N16

NM_001082

NM_024444

NP_001073

NP_077764

Leukotriene-B(4) omega-hydroxylase 1 is an enzyme that in humans is encoded by the CYP4F2 gene.

This gene encodes a member of the superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, fatty acids, and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.

CYP4F2 along with CYP4A22, CYP4A11, and CYP4F3 and CYP2U1 also metabolize arachidonic acid to 20-Hydroxyeicosatetraenoic acid (20-HETE) by an Omega oxidation reaction with the predominant 20-HETE-synthesizing enzymes in humans being CYP4F2 followed by CYP4A11; 20-HETE regulates blood flow, vascularization, blood pressure, and kidney tubule absorption of ions in rodents and possibly humans. Gene polymorphism variants of CYP4F2 are associated with the development of hypertension, cerebral infarction (i.e. ischemic stroke), and myocardial infarction in humans (see 20-Hydroxyeicosatetraenoic acid for details).,

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