CYP4A22

CYP4A22
Identifiers
Aliases	CYP4A22, cytochrome P450 family 4 subfamily A member 22
External IDs	MGI: 88612 HomoloGene: 134044 GeneCards: CYP4A22
EC number	1.14.13.205
Gene ontology Molecular function • iron ion binding • oxidoreductase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • metal ion binding • monooxygenase activity Cellular component • organelle membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • intracellular membrane-bounded organelle • integral component of membrane Biological process • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	284541	277753
Ensembl	ENSG00000162365	ENSMUSG00000066071
UniProt	Q5TCH4	Q91WL5
RefSeq (mRNA)	NM_001010969 NM_001308102	NM_177406
RefSeq (protein)	NP_001010969 NP_001295031 NP_001295031.1	NP_803125
Location (UCSC)	Chr 1: 47.14 – 47.15 Mb	Chr 4: 115.3 – 115.33 Mb
PubMed search

284541

277753

ENSG00000162365

ENSMUSG00000066071

Q5TCH4

Q91WL5

NM_001010969
NM_001308102

NM_177406

NP_001010969
NP_001295031
NP_001295031.1

NP_803125

CYP4A22 (cytochrome P450, family 4, subfamily A, polypeptide 22) also known as fatty acid omega-hydroxylase is a protein which in humans is encoded by the CYP4A22 gene.

This gene encodes a member of the superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.

CYP4A22 was once considered, along with CYP4A11, CYP4F2, and CYP4F3, as active in metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) by an omega oxidation reaction with the predominant 20-HETE-synthesizing enzymes in humans being CYP4F2 followed by CYP4A11; 20-HETE regulates blood flow, vascularization, blood pressure, and kidney tubule absorption of ions in rodents and possibly humans. However, human CYP4A22 is expressed at very low levels in few tissues and may not be a functional enzyme in regard to the metabolism of arachidnoic acid to 20-HETE.

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Wikipedia