CYP4A11

CYP4A11
Identifiers
Aliases	CYP4A11, CP4Y, CYP4A2, CYP4AII, cytochrome P450 family 4 subfamily A member 11
External IDs	MGI: 3028580 HomoloGene: 128044 GeneCards: CYP4A11
EC number	1.14.13.205
Gene ontology Molecular function • iron ion binding • leukotriene-B4 20-monooxygenase activity • arachidonic acid epoxygenase activity • metal ion binding • alkane 1-monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • oxygen binding • monooxygenase activity Cellular component • cytoplasm • organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • membrane • apical plasma membrane • endoplasmic reticulum • extracellular exosome Biological process • leukotriene metabolic process • epoxygenase P450 pathway • fatty acid metabolic process • pressure natriuresis • omega-hydroxylase P450 pathway • renal water homeostasis • positive regulation of icosanoid secretion • sodium ion homeostasis • long-chain fatty acid metabolic process • oxidation-reduction process • leukotriene B4 catabolic process • arachidonic acid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1579	666168
Ensembl	n/a	ENSMUSG00000028712
UniProt	Q02928	n/a
RefSeq (mRNA)	NM_000778 NM_001319155	NM_001252539 NM_201640
RefSeq (protein)	NP_000769 NP_001306084	n/a
Location (UCSC)	Chr 1: 46.93 – 46.94 Mb	Chr 4: 115.56 – 115.58 Mb
PubMed search

1579

666168

n/a

ENSMUSG00000028712

Q02928

n/a

NM_000778
NM_001319155

NM_001252539
NM_201640

NP_000769
NP_001306084

n/a

Cytochrome P450 4A11 is a protein that in humans is encoded by the CYP4A11 gene.

This gene encodes a member of the superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.

CYP4A11 is highly expressed in the liver and kidney.

CYP4A11 along with CYP4A22, CYP4F2, and CYP4F3 metabolize arachidonic acid to 20-Hydroxyeicosatetraenoic acid (20-HETE) by an Omega oxidation reaction with the predominant 20-HETE-synthesizing enzymes in humans being CYP4F2 followed by CYP4A11; 20-HETE regulates blood flow, vascularization, blood pressure, and kidney tubule absorption of ions in rodents and possibly humans. Gene polymorphism variants of CYP4A11 are associated with the development of hypertension and cerebral infarction (i.e. ischemic stroke) in humans (see 20-Hydroxyeicosatetraenoic acid). In its capacity to form hydroxyl fatty acid, CYP4A11 is classified as a CYP monooxygease.

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Wikipedia