CLTC

CLTC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XZG, 4G55
Identifiers
Aliases	CLTC, CHC, CHC17, CLH-17, CLTCL2, Hc, clathrin heavy chain
External IDs	MGI: 2388633 HomoloGene: 3572 GeneCards: CLTC
Gene ontology Molecular function • protein binding • double-stranded RNA binding • protein kinase binding • structural molecule activity • RNA binding • clathrin light chain binding • disordered domain specific binding Cellular component • extracellular vesicle • cytosol • clathrin-coated endocytic vesicle membrane • clathrin coat of coated pit • trans-Golgi network membrane • clathrin coat of trans-Golgi network vesicle • focal adhesion • melanosome • plasma membrane • protein complex • endolysosome membrane • clathrin-coated pit • extracellular exosome • cytoplasmic vesicle membrane • cytoplasmic vesicle • clathrin-coated vesicle • extracellular matrix • membrane • mitotic spindle microtubule • cytoplasm • lysosome • endosome • spindle • cytoskeleton • clathrin coat • clathrin complex • intracellular Biological process • antigen processing and presentation of exogenous peptide antigen via MHC class II • transferrin transport • receptor internalization • negative regulation of protein localization to plasma membrane • retrograde transport, endosome to Golgi • osteoblast differentiation • vesicle-mediated transport • negative regulation of hyaluronan biosynthetic process • intracellular protein transport • Wnt signaling pathway, planar cell polarity pathway • regulation of mitotic spindle organization • autophagy • microtubule-based movement • cell cycle • cell division • membrane organization • mitotic cell cycle • receptor-mediated endocytosis • low-density lipoprotein particle receptor catabolic process • low-density lipoprotein particle clearance • clathrin coat assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1213	67300
Ensembl	ENSG00000141367	ENSMUSG00000047126
UniProt	Q00610	Q68FD5
RefSeq (mRNA)	NM_001288653 NM_004859	NM_001003908
RefSeq (protein)	NP_001275582 NP_004850	NP_001003908.1 NP_001003908
Location (UCSC)	Chr 17: 59.62 – 59.7 Mb	Chr 11: 86.69 – 86.76 Mb
PubMed search

2XZG, 4G55

1213

67300

ENSG00000141367

ENSMUSG00000047126

Q00610

Q68FD5

NM_001288653
NM_004859

NM_001003908

NP_001275582
NP_004850

NP_001003908.1
NP_001003908

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.

CLTC has been shown to interact with PICALM and HGS.

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Wikipedia