HGS (gene)

HGS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D3G, 3F1I, 3OBQ, 3ZYQ, 4AVX
Identifiers
Aliases	HGS, HRS, hepatocyte growth factor-regulated tyrosine kinase substrate
External IDs	MGI: 104681 HomoloGene: 37954 GeneCards: HGS
Gene ontology Molecular function • protein domain specific binding • metal ion binding • protein binding Cellular component • endosome • early endosome membrane • multivesicular body membrane • intracellular membrane-bounded organelle • membrane • ESCRT-0 complex • early endosome • extracellular exosome • cytoplasm • lysosome • cytosol Biological process • protein localization to membrane • protein targeting to lysosome • negative regulation of epidermal growth factor receptor signaling pathway • membrane invagination • multivesicular body assembly • endosomal transport • positive regulation of gene expression • transport • regulation of protein catabolic process • protein transport • regulation of MAP kinase activity • positive regulation of exosomal secretion • intracellular protein transport • signal transduction • negative regulation of cell proliferation • negative regulation of JAK-STAT cascade • macroautophagy • protein deubiquitination • membrane organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9146	15239
Ensembl	ENSG00000185359	ENSMUSG00000025793
UniProt	O14964	Q99LI8
RefSeq (mRNA)	NM_004712	NM_001159328 NM_008244
RefSeq (protein)	NP_004703	NP_001152800.1 NP_032270.3 NP_001152800 NP_032270
Location (UCSC)	Chr 17: 81.68 – 81.7 Mb	Chr 11: 120.47 – 120.48 Mb
PubMed search

2D3G, 3F1I, 3OBQ, 3ZYQ, 4AVX

9146

15239

ENSG00000185359

ENSMUSG00000025793

O14964

Q99LI8

NM_004712

NM_001159328
NM_008244

NP_004703

NP_001152800.1
NP_032270.3
NP_001152800
NP_032270

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.

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