PICALM

PICALM

Protein PICALM PDB 1hf8.png

Identifiers

PICALM, CALM, CLTH, LAP, phosphatidylinositol binding clathrin assembly protein

External IDs

MGI: 2385902 HomoloGene: 111783 GeneCards: PICALM

Gene ontology
Molecular function	• clathrin heavy chain binding • clathrin adaptor activity • clathrin binding • 1-phosphatidylinositol binding • protein binding • phospholipid binding • cadherin binding
Cellular component	• clathrin coat of coated pit • Golgi apparatus • postsynaptic membrane • membrane • neurofibrillary tangle • neuronal cell body • clathrin-coated pit • AP-2 adaptor complex • presynaptic membrane • cytoplasmic vesicle • nucleus • clathrin-coated vesicle • intracellular • vesicle • perinuclear region of cytoplasm • cytosol • intracellular membrane-bounded organelle
Biological process	• regulation of endocytosis • endocytosis • protein complex assembly • iron ion homeostasis • receptor internalization • positive regulation of neuron death • regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process • negative regulation of gene expression • regulation of protein localization • negative regulation of receptor-mediated endocytosis • positive regulation of transcription, DNA-templated • endosomal transport • clathrin coat assembly • cell proliferation • vesicle-mediated transport • axonogenesis • hemopoiesis • clathrin-dependent endocytosis • negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process • synaptic vesicle maturation • positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process • cargo loading into vesicle • receptor-mediated endocytosis • dendrite morphogenesis • positive regulation of beta-amyloid formation • membrane organization • iron ion import across plasma membrane
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE PICALM 212506 at fs.png

PBB GE PICALM 215236 s at fs.png

PBB GE PICALM 212511 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


8301


233489


ENSG00000073921


ENSMUSG00000039361


Q13492


Q7M6Y3

RefSeq (mRNA)


NM_001008660 NM_001206946 NM_001206947 NM_007166

NM_001252520 NM_001252521 NM_001252522 NM_001252523 NM_001252524
NM_146194

RefSeq (protein)


NP_001008660 NP_001193875 NP_001193876 NP_009097 NP_001008660.1

NP_001239449.1 NP_001239450.1 NP_001239451.1 NP_001239452.1 NP_001239453.1
NP_666306.2 NP_001239449 NP_001239450 NP_001239451 NP_001239452 NP_001239453 NP_666306

Location (UCSC)

Chr 11: 85.96 – 86.07 Mb

Chr 7: 90.13 – 90.21 Mb

PubMed search

ENSG00000073921

ENSMUSG00000039361

NM_001008660
NM_001206946
NM_001206947
NM_007166

NP_001008660
NP_001193875
NP_001193876
NP_009097
NP_001008660.1

NP_666306.2
NP_001239449
NP_001239450
NP_001239451
NP_001239452
NP_001239453
NP_666306

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Wikipedia

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