CEBPE

CEBPE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T92
Identifiers
Aliases	CEBPE, C/EBP-epsilon, CRP1, CCAAT/enhancer binding protein epsilon
External IDs	MGI: 103572 HomoloGene: 1367 GeneCards: CEBPE
Genetically Related Diseases
acute lymphocytic leukemia,
Gene ontology Molecular function • protein heterodimerization activity • transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein homodimerization activity Cellular component • nucleus • nucleoplasm Biological process • defense response • myeloid cell differentiation • positive regulation of gene expression • cellular response to lipopolysaccharide • regulation of transcription, DNA-templated • defense response to bacterium • cytokine biosynthetic process • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • macrophage differentiation • phagocytosis • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1053	110794
Ensembl	ENSG00000092067	ENSMUSG00000052435
UniProt	Q15744	Q6PZD9
RefSeq (mRNA)	NM_001805	NM_207131
RefSeq (protein)	NP_001796	NP_997014.1 NP_997014
Location (UCSC)	Chr 14: 23.12 – 23.12 Mb	Chr 14: 54.71 – 54.71 Mb
PubMed search

3T92

1053

110794

ENSG00000092067

ENSMUSG00000052435

Q15744

Q6PZD9

NM_001805

NM_207131

NP_001796

NP_997014.1
NP_997014

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene and is pro-apoptotic.

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.

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