CEBPD

CEBPD
Identifiers
Aliases	CEBPD, C/EBP-delta, CELF, CRP3, NF-IL6-beta, CCAAT/enhancer binding protein delta
External IDs	MGI: 103573 HomoloGene: 3808 GeneCards: CEBPD
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • protein heterodimerization activity • protein homodimerization activity • transcription regulatory region DNA binding Cellular component • nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • hematopoietic progenitor cell differentiation • positive regulation of osteoblast differentiation • negative regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • fat cell differentiation • inner ear development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1052	12609
Ensembl	ENSG00000221869	ENSMUSG00000071637
UniProt	P49716	Q00322
RefSeq (mRNA)	NM_005195	NM_007679
RefSeq (protein)	NP_005186	NP_031705.3 NP_031705
Location (UCSC)	Chr 8: 47.74 – 47.74 Mb	Chr 16: 15.89 – 15.89 Mb
PubMed search

1052

12609

ENSG00000221869

ENSMUSG00000071637

P49716

Q00322

NM_005195

NM_007679

NP_005186

NP_031705.3
NP_031705

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.

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