CDKN2B

CDKN2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D9S
Identifiers
Aliases	CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase inhibitor 2B, cyclin dependent kinase inhibitor 2B
External IDs	MGI: 104737 HomoloGene: 55859 GeneCards: CDKN2B
Gene ontology Molecular function • protein binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • protein kinase binding Cellular component • cytoplasm • cytosol • nucleus Biological process • cellular response to extracellular stimulus • megakaryocyte differentiation • positive regulation of transforming growth factor beta receptor signaling pathway • regulation of cyclin-dependent protein serine/threonine kinase activity • mitotic cell cycle checkpoint • spleen development • cellular response to nutrient • negative regulation of G1/S transition of mitotic cell cycle • G2/M transition of mitotic cell cycle • cell cycle arrest • negative regulation of epithelial cell proliferation • cell cycle • negative regulation of phosphorylation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • negative regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1030	12579
Ensembl	ENSG00000147883	ENSMUSG00000073802
UniProt	P42772	P55271
RefSeq (mRNA)	NM_078487 NM_004936	NM_007670
RefSeq (protein)	NP_004927 NP_511042	NP_031696.1 NP_031696
Location (UCSC)	Chr 9: 22 – 22.01 Mb	Chr 4: 89.31 – 89.31 Mb
PubMed search

1D9S

1030

12579

ENSG00000147883

ENSMUSG00000073802

P42772

P55271

NM_078487
NM_004936

NM_007670

NP_004927
NP_511042

NP_031696.1
NP_031696

Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15^INK4b is a protein that is encoded by the CDKN2B gene in humans.

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, also known as p15Ink4b protein, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases by cyclin D, thus the encoded protein functions as a cell growth regulator that inhibits cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

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