CDK6

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1BI7, 1BI8, 1BLX, 1G3N, 1JOW, 1XO2, 2EUF, 2F2C, 3NUP, 3NUX, 4AUA, 4EZ5, 4TTH

Identifiers

Aliases

CDK6, MCPH12, PLSTIRE, cyclin-dependent kinase 6, cyclin dependent kinase 6

External IDs

OMIM: 603368 MGI: 1277162 HomoloGene: 963 GeneCards: CDK6

Genetically Related Diseases

rheumatoid arthritis

Targeted by Drug

palbociclib

Gene ontology
Molecular function	• transferase activity • protein kinase activity • nucleotide binding • cyclin-dependent protein serine/threonine kinase activity • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • cyclin binding • FBXO family protein binding
Cellular component	• cytoplasm • centrosome • cell projection • cyclin-dependent protein kinase holoenzyme complex • ruffle • nucleoplasm • microtubule organizing center • cytoskeleton • nucleus • cytosol • cyclin D2-CDK6 complex
Biological process	• Notch signaling pathway • cell differentiation • hemopoiesis • T cell differentiation in thymus • lateral ventricle development • phosphorylation • positive regulation of cell-matrix adhesion • positive regulation of fibroblast proliferation • dentate gyrus development • regulation of erythrocyte differentiation • astrocyte development • G1/S transition of mitotic cell cycle • negative regulation of cell differentiation • response to virus • negative regulation of cell cycle • negative regulation of osteoblast differentiation • generation of neurons • cell division • regulation of cell motility • protein phosphorylation • positive regulation of gene expression • hematopoietic stem cell differentiation • cell cycle arrest • hematopoietic progenitor cell differentiation • negative regulation of epithelial cell proliferation • regulation of gene expression • cell cycle • type B pancreatic cell development • negative regulation of myeloid cell differentiation • negative regulation of cellular senescence • gliogenesis • negative regulation of cell proliferation • negative regulation of monocyte differentiation • cellular response to phorbol 13-acetate 12-myristate • negative regulation of transcription from RNA polymerase II promoter • signal transduction • regulation of G2/M transition of mitotic cell cycle • cell dedifferentiation • regulation of hematopoietic stem cell differentiation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1021


12571

Ensembl


ENSG00000105810


ENSMUSG00000040274

UniProt


Q00534


Q64261

RefSeq (mRNA)


NM_001145306 NM_001259


NM_009873

RefSeq (protein)


NP_001138778 NP_001250


NP_034003.1

Location (UCSC)

Chr 7: 92.6 – 92.84 Mb

Chr 5: 3.34 – 3.53 Mb

PubMed search

1BI7, 1BI8, 1BLX, 1G3N, 1JOW, 1XO2, 2EUF, 2F2C, 3NUP, 3NUX, 4AUA, 4EZ5, 4TTH

NM_001145306
NM_001259

NM_009873

NP_001138778
NP_001250

...
Wikipedia