CDK4

CDK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK
Identifiers
Aliases	CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4
External IDs	OMIM: 123829 MGI: 88357 HomoloGene: 55429 GeneCards: CDK4
Targeted by Drug
alvocidib, palbociclib
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • cyclin-dependent protein serine/threonine kinase activity • protein complex binding • kinase activity • protein serine/threonine kinase activity • cyclin-dependent protein serine/threonine kinase regulator activity • protein binding • ATP binding • cyclin binding Cellular component • cytoplasm • cytosol • cyclin-dependent protein kinase holoenzyme complex • nuclear membrane • membrane • transcription factor complex • bicellular tight junction • nucleoplasm • nucleolus • perinuclear region of cytoplasm • chromatin • nucleus • protein complex • cyclin D2-CDK4 complex Biological process • phosphorylation • response to testosterone • positive regulation of fibroblast proliferation • response to hyperoxia • G1/S transition of mitotic cell cycle • positive regulation of translation • regulation of cell cycle • cell division • negative regulation of cell cycle arrest • protein phosphorylation • lens development in camera-type eye • regulation of cell proliferation • response to lead ion • circadian rhythm • animal organ regeneration • positive regulation of cell proliferation • positive regulation of cell size • positive regulation of apoptotic process • regulation of gene expression • cell cycle • positive regulation of G2/M transition of mitotic cell cycle • response to toxic substance • positive regulation of cell cycle • regulation of protein kinase activity • signal transduction • multicellular organism development • response to organic substance • cellular response to insulin stimulus • regulation of multicellular organism growth • regulation of insulin receptor signaling pathway • regulation of lipid biosynthetic process • regulation of lipid catabolic process • adipose tissue development • cellular response to lipopolysaccharide • cellular response to interleukin-4 • cellular response to phorbol 13-acetate 12-myristate • cellular response to ionomycin • response to drug Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1019	12567
Ensembl	ENSG00000135446	ENSMUSG00000006728
UniProt	P11802	P30285
RefSeq (mRNA)	NM_052984 NM_000075	NM_009870
RefSeq (protein)	NP_000066	NP_034000.1 NP_034000
Location (UCSC)	Chr 12: 57.75 – 57.76 Mb	Chr 10: 127.06 – 127.07 Mb
PubMed search

2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK

1019

12567

ENSG00000135446

ENSMUSG00000006728

P11802

P30285

NM_052984
NM_000075

NM_009870

NP_000066

NP_034000.1
NP_034000

Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. CDK4 is a member of the cyclin-dependent kinase family.

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