CD80

CD80
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DR9, 1I8L
Identifiers
Aliases	CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule
External IDs	OMIM: 112203 MGI: 101775 HomoloGene: 3804 GeneCards: CD80
Gene ontology Molecular function • coreceptor activity • virus receptor activity • protein binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • membrane • cell surface • external side of plasma membrane • integral component of membrane • plasma membrane • intracellular • protein complex involved in cell adhesion Biological process • T cell costimulation • intracellular signal transduction • phosphatidylinositol-mediated signaling • positive regulation of interleukin-2 biosynthetic process • positive regulation of alpha-beta T cell proliferation • cell-cell signaling • positive regulation of signal transduction • cellular response to lipopolysaccharide • positive regulation of T-helper 1 cell differentiation • viral process • viral entry into host cell • positive regulation of T cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of transcription, DNA-templated • positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process • T cell activation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	941	12519
Ensembl	ENSG00000121594	ENSMUSG00000075122
UniProt	P33681	Q00609
RefSeq (mRNA)	NM_005191	NM_009855
RefSeq (protein)	NP_005182	NP_033985.3 NP_033985
Location (UCSC)	Chr 3: 119.52 – 119.56 Mb	Chr 16: 38.46 – 38.49 Mb
PubMed search

1DR9, 1I8L

941

12519

ENSG00000121594

ENSMUSG00000075122

P33681

Q00609

NM_005191

NM_009855

NP_005182

NP_033985.3
NP_033985

Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells.

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