CTLA-4

CTLA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7
Identifiers
Aliases	CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
External IDs	OMIM: 123890 MGI: 88556 HomoloGene: 3820 GeneCards: CTLA4
Genetically Related Diseases
rheumatoid arthritis, hypothyroidism, type 1 diabetes mellitus
Gene ontology Molecular function • protein binding Cellular component • perinuclear region of cytoplasm • integral component of membrane • clathrin-coated endocytic vesicle • plasma membrane • Golgi apparatus • integral component of plasma membrane • membrane • external side of plasma membrane • protein complex involved in cell adhesion Biological process • B cell receptor signaling pathway • T cell costimulation • negative regulation of B cell proliferation • adaptive immune response • negative regulation of regulatory T cell differentiation • immune response • cellular response to DNA damage stimulus • immune system process • positive regulation of apoptotic process • negative regulation of immune response • negative regulation of T cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1493	12477
Ensembl	ENSG00000163599	n/a
UniProt	P16410	P09793
RefSeq (mRNA)	NM_001037631 NM_005214	NM_001281976 NM_009843
RefSeq (protein)	NP_001032720 NP_005205	NP_033973.2
Location (UCSC)	Chr 2: 203.87 – 203.87 Mb	Chr 1: 60.89 – 60.92 Mb
PubMed search

3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7

1493

12477

ENSG00000163599

n/a

P16410

P09793

NM_001037631
NM_005214

NM_001281976
NM_009843

NP_001032720
NP_005205

NP_033973.2

CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. CTLA4 is constitutively expressed in Tregs but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.

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