CD28

CD28
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YJD, 3WA4, 5AUL
Identifiers
Aliases	CD28, Tp44, CD28 molecule
External IDs	MGI: 88327 HomoloGene: 4473 GeneCards: CD28
Gene ontology Molecular function • coreceptor activity • protease binding • protein binding • identical protein binding • protein kinase binding • SH3/SH2 adaptor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • integral component of membrane • cytosol • membrane • plasma membrane • integral component of plasma membrane • immunological synapse • external side of plasma membrane • cell surface • protein complex involved in cell adhesion Biological process • positive regulation of protein kinase B signaling • regulatory T cell differentiation • regulation of regulatory T cell differentiation • T cell costimulation • regulation of defense response to virus by virus • positive regulation of translation • negative regulation of gene expression • cytokine biosynthetic process • positive regulation of interleukin-2 biosynthetic process • negative thymic T cell selection • cell surface receptor signaling pathway • positive regulation of gene expression • humoral immune response • positive regulation of T cell proliferation • positive regulation of alpha-beta T cell proliferation • immune response • apoptotic signaling pathway • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of isotype switching to IgG isotypes • positive regulation of viral genome replication • T cell receptor signaling pathway • positive regulation of mitotic nuclear division • phosphatidylinositol-mediated signaling • positive regulation of inflammatory response to antigenic stimulus • positive regulation of transcription from RNA polymerase II promoter • positive regulation of interleukin-10 production • phosphatidylinositol phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of interleukin-4 production Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	940	12487
Ensembl	ENSG00000178562	n/a
UniProt	P10747	P31041
RefSeq (mRNA)	NM_001243077 NM_001243078 NM_006139	NM_007642
RefSeq (protein)	NP_001230006 NP_001230007 NP_006130	NP_031668.3 NP_031668
Location (UCSC)	Chr 2: 203.71 – 203.74 Mb	Chr 1: 60.72 – 60.77 Mb
PubMed search

1YJD, 3WA4, 5AUL

940

12487

ENSG00000178562

n/a

P10747

P31041

NM_001243077
NM_001243078
NM_006139

NM_007642

NP_001230006
NP_001230007
NP_006130

NP_031668.3
NP_031668

CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular).

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Wikipedia